Prostacyclin analogues

Details Prostacyclin analogues Prostacyclin analogues

1979-11-27

1983-01-04

Raymond, Richard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Allergen or component thereof

2603303, 424180, 42424851, 424250, 424263, 424267, 424274, 536103, 542426, 542429, 544145, 544376, 546202, 546274, 549 23, 549 51, 549 53, 549 58, 548525, A61K 3138, C07D33378

Patent

active

043672370

ABSTRACT:
Prostaglandin analogues of the general formula: ##STR1## [wherein the ring A represents: ##STR2## the ring B represents: ##STR3## (wherein R.sup.6 represents hydrogen, methyl or ethyl, and r is zero, one or two), Y represents ethylene, cis- or trans-vinylene or ethynylene, Z represents a grouping of the formula: --(CH.sub.2).sub.m --, --(CH.sub.2).sub.3 --CHR.sup.7 --, --(CH.sub.2).sub.2 --CHR.sup.7 --CH.sub.2 --, --CH.sub.2 --CHR.sup.7 --(CH.sub.2).sub.2 --, --CHR.sup.7 --(CH.sub.2).sub.3 --, or trans--(CH.sub.2).sub.2 --CH.dbd.CH-- (wherein m is 3, 4 or 5, and R.sup.7 represents methyl or ethyl), R.sup.1 represents a grouping of the formula: --COOR.sup.8, ##STR4## or --CH.sub.2 OR.sup.11 (wherein R.sup.8 represents hydrogen, alkyl, aralkyl, cycloalkyl which is unsubstituted or substituted by at least one alkyl group, or R.sup.8 represents phenyl which is unsubstituted or substituted by halogen, trifluoromethyl, alkyl, alkoxy, alkylthio or phenyl, or represents naphthyl, 2,3- or 1,3-dihydroxypropyl, 2,3- or 1,3-bisalkanoyloxypropyl, a grouping of the formula: -D.sub.1 --COOR.sup.12, ##STR5## -D.sub.2 -R.sup.15 or -D.sub.3 -R.sup.16, wherein D.sub.1 represents alkylene, D.sub.2 represents alkylene, D.sub.3 represents a single bond or alkylene, R.sup.12, R.sup.13 and R.sup.14, each represent alkyl, R.sup.15 represents hydroxy, alkoxy or alkylthio and R.sup.16 represents a heterocyclic ring, or R.sup.8 represents a grouping of the formula: ##STR6## R.sup.9 and R.sup.10, each represent hydrogen, alkyl, alkylsulphonyl, alkanoyl or ##STR7## represents a heterocyclic ring, and R.sup.11 represents hydrogen or alkanoyl, R.sup.2 represents hydrogen, methyl or ethyl, R.sup.3 represents a single bond or alkylene, R.sup.4 represents hydrogen, alkyl, alkoxy, cycloalkyl or cycloalkyloxy unsubstituted or substituted by alkyl, or represents phenyl or phenoxy unsubstituted or substituted by halogen, trifluoromethyl or alkyl with the proviso that, when R.sup.3 represents a single bond, R.sup.4 does not represent alkoxy, cycloalkyloxy or phenoxy, R.sup.5 represents hydrogen, methyl or ethyl and with the proviso that, when one of the groups R.sup.5, R.sup.6 and R.sup.7 represents methyl or ethyl the other two groups are hydrogen atoms] and cyclodextrin clathrates, non-toxic salts and non-toxic acid addition salts thereof, possess selective strong stimulatory activity on uterine contraction in female mammals.

REFERENCES:
patent: 4150222 (1979-04-01), Johnson
patent: 4158667 (1979-06-01), Axen
patent: 4178367 (1979-12-01), Masaki et al.
patent: 4180512 (1979-12-01), Smith
patent: 4187381 (1980-02-01), Holland et al.
patent: 4208428 (1980-06-01), Kurono et al.
patent: 4258199 (1981-03-01), Nicolaou et al.
patent: 4271184 (1981-06-01), Gandolfi et al.
patent: 4291166 (1981-09-01), Nicolaou et al.
Nicolaou et al, J. Chem. Soc. Chem. Comm. 1978, pp. 375 to 377.
Nicolaou et al, J. Am. Chem. Soc. vol. 100, pp. 2567 to 2570 (4-12-78).
Gryglewski et al, Experientia vol. 34, pp. 1336 to 1338 (10-15-78).
Shibasaki et al, Tetrahedron Letters, No. 6, pp. 559-562 (Jun. 1978).
Horii et al, Eur. J. Pharmacol. 1978, pp. 313-316, vol. 51, No. 3.
Shimoji et al, Chem. Lett. 1978 (12), 1375-1376.
Derwent of Japanese 130,665 (5-29-79).

Affiliated with

Also associated with

Rating

Prostacyclin analogues does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Prostacyclin analogues, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Prostacyclin analogues will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1581717