Prostacyclin analogs and their use in inhibition of arachidonic

Details Prostacyclin analogs and their use in inhibition of arachidonic Prostacyclin analogs and their use in inhibition of arachidonic

1979-04-25

1980-03-11

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424317, 560119, 562501, 2604488R, C07C17700, C07C 6938, C07C 6974

Patent

active

041928911

ABSTRACT:
Prostacyclin analogs are provided having the structure ##STR1## wherein X represents .dbd.O or OH, R.sub.1 and R.sub.2 are OH or H, provided at least one of R.sub.1 and R.sub.2 is other than hydroxyl, R.sub.3 is H or alkyl of 1 to 4 carbons, m is an integer of from 2 to 5, and n is an integer of from 2 to 10, or pharmaceutically acceptable salts thereof. These compounds have been found to be potent inhibitors of arachidonic acid-induced platelet aggregation and bronchoconstriction.

REFERENCES:
Nicolaov et al., Chem. Comm. 1067 (1978).

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