Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – C-o-group doai
Patent
1999-04-05
2000-08-08
Cook, Rebecca
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
C-o-group doai
514816, 514938, A61K 3105
Patent
active
061003026
ABSTRACT:
Formulations of intravenous anesthetic propofol emulsions are provided which contain sufficiently low concentrations of soybean oil to produce a stable emulsion and simultaneously provide reduced nutrients, which inhibit microbial growth thereby providing protection against accidental microbial contamination during long-term IV infusions. In addition to the inhibition of microbial growth due to a reduction of nutrients, the formulation exhibits unanticipated additional microbial inhibition due to an increased availability of propofol. The low concentration of soybean oil also provides a formulation that reduces the chances of fat overload when administered over an extended period of time to chronically ill patients.
REFERENCES:
patent: 5688528 (1997-11-01), Carlsson et al.
patent: 5714520 (1998-02-01), Jones et al.
dela Rosa Josben C.
Motheram Rajeshwar
Pejaver Satish K.
Rabinow Barrett E.
Baxter International Inc.
Buonaiuto Mark J.
Cook Rebecca
Kowalik Frances C.
Nichols Jeffrey C.
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