Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – C-o-group doai
Patent
1995-03-22
1998-02-03
Jarvis, William R.A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
C-o-group doai
A61K 3105
Patent
active
057145202
ABSTRACT:
Sterile pharmaceutical compositions for parenteral administration containing 2,6-diisopropylphenol (propofol) are described for use as anesthetics. The compositions comprise an oil-in-water emulsion of propofol additionally containing a amount of edetate sufficient to prevent significant growth of microorganisms for at least 24 hours after adventitious, extrinsic contamination.
REFERENCES:
patent: Re32393 (1987-04-01), Wretlind et al.
patent: 3384545 (1968-05-01), Aiello et al.
patent: 4056635 (1977-11-01), Glen et al.
patent: 4452817 (1984-06-01), Glen et al.
patent: 4567161 (1986-01-01), Posanski et al.
patent: 4798846 (1989-01-01), Glen et al.
Russell et al., Ethylenediaminetetra-acetic acid, Inhibition and Destruction of the Microbial Cell, 1971, pp. 209-224.
Chew et al., In Vitro Growth Inhibition of Mastitis Causing Bacteria by Phenolics and Metal Chelators, Journal of Dairy Science, 1985, 68, pp. 3037-3046.
Morita et al., The Effects of Copper and EDTA on the Autoxidation of Phospholipid Emulsions, Agr. Biol. Chem., 1972, vol. 36, No. 7, pp. 1163-1167.
Hart et al., Chelating Agents as Preservative Potentiators, Cosmetic and Drug Preservation: Principles and Practice, Chapter 18, 1985, pp. 323-337.
Postsurgical Infections Associated with an Extrinsically Contaminated Intravenous Anesthetic Agent -California, Illinois, Maine, and Michigan, 1990, Morbidity and Mortality Weekly Report (MMR), Jun. 29, 1990, pp. 426-427, 433.
Trissel, Handbook on Injectable Drugs, 1994, 8th Edition, pp. 63, 115, 125-127, 133, 269, 308, 314-316, 318-319, 484-485, 536-537, 590-591, 612-613, 687-689, 722-723, 664-665, 770-771, 815, 902-903, 920-921, 934-935, 1007, 1104.
Nakamura et al., Direct Vasoconstrictor And Vasodilator Effects Of Propofol In Isolated Dog Arteries, British Journal of Anaesthesia, Feb. 1992, pp. 193-197.
Patel et al., Dosodium Salt Of EDTA As An Antimicrobial Agent, Indian Journal of Pharmacy, May, 1995, pp. 147-148.
Mouton et al., Effect Of I.V. Anaethesia With Propofol On Drug Distribution And Metabolism In The Dog, British Journal of Anaethesia, Jan. 1991, pp. 66-72.
Chemical Abstract No. 113:84881, Morita et al., Ophthalmic Solutions Containg Benzalkonium Chloride, P-hydroxybenzoate Esters and Chelating Agents, Sep. 3, 1990.
Derwent Publication Abstract JP2096515, Apr., 1990.
Patent Abstracts of Japan No. JPA 02096515, Apr., 1990.
Russell, Effect of Magnesium Ions and Ethylenediamine Tetra-acetic Acid on the Activity of Vancomycin against Escherichia coli and Staphylococcus aureus, 1967, J. appl. Bact., 30, 395-401.
Bennett et al., Postoperative Infections Traced to Contamination of an Intravenous Anesthetic, Propofol, The New England Journal of Medicine, Jul., 1995, pp. 147-154.
Simmons, CDC Guidelines for the Prevention and Control of Nosocomial Infections; Guidelines for prevention of intravascular infection, American Journal of Infection Control, Oct., 1983, pp. 183-193.
Crocker et al., Microbial Growth Comparisons of Five Commercial Parenteral Lipid Emulsions, Journal of Parenteral and Enteral Nutrition, 1984, pp. 391-395.
D'Angio et al., The Growth of Microorganisms in Total Parenteral Nutrition Admixtures, Journal of Parenteral and Enteral Nutrition, 1987, pp. 394-397.
Melly et al., Microbial Growth in Lipid Emulsions Used in Parenteral Nutrition, Arch Surg, 1975, pp. 1479-1481.
Gilbert et al., Microbial Growth Patterns in a Total Parenteral Nutrition Formulation Containing Lipid Emulsion, Journal of Parenteral and Enteral Nutrition, 1986, pp. 99. 494-497.
Thompson et al., Infection Control of Parenteral Nutrition Solutions, Nutrition in Clinical Practice, Apr. 1991, pp. 49-54.
Grier et al., So Much Writing, So Little Science: A Review of 37 Years of Literature on Edetate Sodium Chelation Therapy, The Annals of Pharmacotherapy, Dec., 1993, pp. 1504-1509.
Haque and Russell, Effect of Ethylenediaminetetraacetic Acid and Related Chelating Agents on Whole Cells of Gram-Negative Bacteria, Antimicrobial Agents and Chemotherapy, May, 1974, pp. 447-452.
Haque and Russell, Effect of Chelating Agents on the Susceptiblity of Some Strains of Gram-Negative Bacteria to Some Antibacterial Agents, Antimicrobial Agents and Chemotherapy, Aug. 1974, pp. 200-206.
Russell, Modification of the Bacterial Cell Envelope and Enhancement of Antibiotic Susceptibility, Chapter of The Control of Antibiotic-Resistant Bacteria, Academic Press, 1982, pp. 119-165.
Hart, EDTA-Type Chelating Agents in Personal Care Products, Cosmetics & Toiletries, Apr. 1983, pp. 54-58.
Hart, Chelating agents in cosmetic and toiletry products, Cosmetics & Toiletries, Dec. 1978, pp. 28-30.
Hart, EDTA-Type Chelating Agents in Everyday Consumer Products: Some Medicinal and Personal Care Products, Journal of Chemical Education, Dec. 1984, pp. 1060-1061.
Kabara, GRAS antimicrobial agents for cosmetic products, J. Soc. Cosmet. Chem., Jan./Feb. 1980, pp. 1-10.
Kraniak et al., Effect of Ethylenediaminetetraacetic Acid (EDTA) and Metal ions on Growth of Staphylococcus aureus 196E in Culture Media, Journal of Food Science, 1988, pp. 910-913.
Bhagat et al., Growth response of Pseudomonas stutzeri RS34 to ethylenediaminetetraacetic acid (EDTA) and its interaction with zinc, Indian Journal of Experimental Biology, Jul. 1993, pp. 590-594.
Houben et al., Controlling Growth of Streptococcus faecium in a Ham Model with Heat and Ethylenediamine Tetraacetic Acid, Tertiary butylhydroquinone or Nisin, Meat Science, 1985, pp. 205-215.
Trissel, Handbook of Injectable Drugs, 1994, pp. 381-383.
Martindale's Pharmacopeia, 1993, p. 681.
U.S. Data Sheet for Edetate Disodium, 1990.
Professional Information Brochure, DIPRIVAN (propofol) Injection, Emulsion For IV Administration, Rev L Oct. 1994.
Parenteral Preparations, British Pharmacopoeia 1993, vol. II, pp. 746-747.
The Pharmaceutical CODEX, Principles and Practice of Pharmaceutics, Twelfth Edition, pp. 102-103, 1992.
The United States Pharmacopeia, The National Formulary, 1995, pp. 1650-1652; 1733-1735; 1681.
Trissel, Handbook of Injectable Drugs, 1994, pp. 464-465, 558-559, 593-9 and 662-663.
Shooter et al., Mineral Requirements for Growth of Staphylococcus Pyrogenes, Effect of Magnesium and Calcium Ions, The British Journal of Experimental Pathology, 1955, pp. 341-350.
Sack et al., Factors Affecting The Production of Staphylocoagulase in a Chemically Defined Medium, The Ohio Journal of Science, Sep., 1963, pp. 232-240.
Jones Christopher Buchan
Platt John Henry
Jarvis William R.A.
Zeneca Limited
LandOfFree
Propofol compostion containing edetate does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Propofol compostion containing edetate, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Propofol compostion containing edetate will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-662836