Propofol composition containing sulfite

Details Propofol composition containing sulfite Propofol composition containing sulfite

1999-02-10

2000-11-14

Jarvis, William R. A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

C-o-group doai

514709, 514712, A61K 3105, A61K 3110

Patent

active

061471224

ABSTRACT:
Sterile pharmaceutical compositions for parenteral administration containing 2,6-diisopropylphenol (propofol) are described for use as anesthetics. The compositions comprise an oil-in-water emulsion of propofol additionally comprising an amount of sulfite sufficient to prevent significant growth of microorganisms for at least 24 h after adventitious contamination.

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Shah, et al.,"Effect of pH, Chlorobutanol, Cysteine Hydrochloride, Ethylenediaminetetraacetic Acid, Propylene Glycol, Sodium Metabisulfite, and Sodium Sulfite on Furosemide Stability in Aqueous Solutions" J. Pharm. Sci. 69(5): 594-596 (1980).

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