Propiophenone derivatives and process for preparing the same

Details Propiophenone derivatives and process for preparing the same Propiophenone derivatives and process for preparing the same

1997-12-18

2000-04-11

Peselev, Elli

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

A61K 3170, C07H 1500

Patent

active

060488425

ABSTRACT:
A propiophenone derivative of the formula (I): ##STR1## wherein OX is a hydroxy group which may optionally be protected, Y is a lower alkyl group, and Z is a .beta.-D-glucopyranosyl group wherein one or more hydroxy groups may optionally be protected, or a pharmaceutically acceptable salt thereof. Said compounds have excellent hypoglycemic activity so that they are useful in the prophylaxis or treatment of diabetes.

REFERENCES:
patent: 3984394 (1976-10-01), Westall et al.
patent: 4031260 (1977-06-01), Westall et al.
patent: 4665058 (1987-05-01), Diedrich et al.
patent: 4684627 (1987-08-01), LeVeen et al.
patent: 4760135 (1988-07-01), Diedrich et al.
patent: 4840939 (1989-06-01), Leveen et al.
patent: 5110801 (1992-05-01), Leveen et al.
Textbook of Diabetes, 2.sup.nd Ed., vol. 2, chap. 83.8-83.13 (1997).
The New England Journal of Medicine, vol. 331, pp. 1118-1193 (1994).
The Journal of Pharmacology and Experimental Therapeutics, vol. 275, pp. 194-199 (1995).
Biochim Biophys. Acta, 71, 668, "The Comparative Effects of Some Phlorizin Analogs on the Renal Reabsorption of Glucose", pp. 688-700, 1963.
Diabetes Cares, vol. 13, No. 6, "Glucose Toxicity", pp. 610-630, 1990.
J. Clin. Invest., vol. 79, Correction of Hyperglycemia with Phlorizin Normalizes Tissue Sensitivity to Insulin in Diabetic Rats, pp. 1510-1515, 1987.
J. Clin. Invest., vol. 80, "Effect of Chronic Hyperglycemia on In Vivo Insulin Secretion in Partially Pancreatectomized Rats", pp. 1037-1044, 1987.
J. Clin. Invest., vol. 87, "Normalization of Blood Glucose in Diabetic Rats with Phlorizin Treatment Reverses Insulin-resistant Glucose Transport in Adipose Cells without Restoring Glucose Transporter Gene Expression", pp. 561-570, 1991.
Diabetologia, vol. 28, "Hyperglycaemia as an inducer as well as a consequence of impaired isle cell function and insulin resistance: implications for the management of diabetes", pp. 119-121, 1985.
Stroke, vol. 14, "Rapid, Transient Drop in Brain Glucose After Intravenous Phloretin or 3-0-Methyl-D-Glucose", pp. 388-393, 1983.
Biochemistry, vol. 8, No. 5, "The Inhibition of Photophosphorylation by Phlorizin and Closely Related Compounds", pp. 2067-2073, 1969.
American Journal of Physiology, vol. 224, No. 3, "Reevaluation of renal tubular glucose transport inhibition by phlorizin analogs", pp. 552-557, 1973.
Archives of Biochemistry and Biophysics, vol. 117, "Competitive Inhibition of Intestinal Glucose Transport by Phlorizin Analogs", pp. 248-256, 1966.
Archives of Biochemistry and Biophysics, vol. 199, No. 2, "The Affinity of Phlorizin-Like Compounds for a .beta.-Glucosidase in Intestin Brush Borders: Comparison with Glucose Transport System", pp. 342-348, 1980.
Biochim. Biophys. Acta, 290, "Inhibition of [.sup.3 H] Phlorizin Binding to Isolated Kidney Brush Border Membranes by Phlorizin-Like Compounds", pp. 134-149, 1972.
J. Nutr. Sci. Vitaminol, 38 (1) pp. 27-37, ISSN 0301-4800, Tokyo, Japan, Feb. 1992.
Diabetes, vol. 37, "Characterization of New Oral Antidiabetic Agent CS-045", pp. 1549-1558, 1988.
Acta Alimentaria, vol. 11 (1), "Effect of a Synthetic Dihydrochalcone Sweetener (Chinoin-401) on Carbohydrate Metabolism", pp. 31-37, 1982.

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