Prophylaxis in the parenteral administration of particulate disp

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Halogenated hydrocarbon doai

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424673, 514748, 514937, 514174, 514182, 514177, A61K 3102, A61K 3103, A61K 3158, A61K 3314

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active

058470093

ABSTRACT:
Methods for preventing or ameliorating the transient adverse physiological response to particulate dispersions (TAPR response) when these dispersions are administered parenterally to a patient. The methods comprise the administration of a prophylactic anti-inflammatory drug prior to administration of the particulate-containing material, and optionally during administration as well. Preferred drugs are cyclooxygenase inhibitors and corticosteroids.

REFERENCES:
patent: 3975512 (1976-08-01), Long, Jr.
patent: 4073879 (1978-02-01), Long, Jr.
patent: 4278654 (1981-07-01), Rakli et al.
patent: 4285928 (1981-08-01), Wada et al.
patent: 4415556 (1983-11-01), Bretschneider
patent: 4865836 (1989-09-01), Long, Jr.
patent: 4927623 (1990-05-01), Long, Jr.
patent: 4951673 (1990-08-01), Long
patent: 4987154 (1991-01-01), Long, Jr.
patent: 5670495 (1997-09-01), Goodin et al.
Abe, H., et al. (1985) Role of histidine-related compounds to intracellular buffering in fish skeletal muscle. Am. J. Physiol. 249:R449-R454.
Aiken, J., et al. (1981) Endogenous prostacyclin contributes to the efficacy of a thromboxane synthetase inhibitor for preventing coronary artery thrombosis. Jour. of Pharmacology and Experimental Therapeutics 219(2):299-308.
Cadnapaphornchai, P., et al. (1982) Effect of imidazole on the recovery from bilateral ureteral obstruction in dogs. Amer. J. Physio. 243:F532-F536.
Cao, Y.-Z., et al. (19870 Regulation by vitamin E of phosphatidylcholine metabolism in rat heart. Biochem. J. 247:135-140.
Ferrari, F. and Baggio, G. (1985) Influence of imidazole on behavioral effects induced by dopaminergic agonists in rats. Life Sciences 36:1397-1405.
Ferrari, F., et al. (1986) Imidazole has similar behavioural effects to yohimbine. Psychopharmacology 88:58-62.
Ferrari, F., et al. (1987) Effects of imidazole and some imidazole-derivatives on lisuride-induced mounting and aggressiveness. Psychopharmacology 93:19-24.
Ferrari, F., et al. (1985) Behavioural pharmacology of imidazole, a potential antidepressant agent. Arch. Int. Pharmacodyn 277:303-312.
Fitzgerald, G.A., et al. (1983) Endogenous prostacyclin biosynthesis and platelet function during selective inhibition of thromboxane synthase in man. J. Clin. Invest. 71:1336-1343.
Golino, P., et al. (1989) Simultaneous administration of thromboxane A.sub.2 --and serotonin S.sub.2 --receptor antagonists markedly enhances thrombolysis and prevents or delays reocclusion after tissue-type plasminogen activator in a canine model of coronary thrombosis. Circulation 79:911-919.
Guo, et al. Liposomes in Drug Delivery: 21 years on the school of pharmacy, University of London, 12th-15th Dec. 1990.
Kazic, T. (1977) Action of methylxanthines and imidazole on the contractility of the terminal ileum of the guinea pig. European J. of Pharmacology 41:103-111.
Kresh, J., et al. (1987) The relative buffering power of cardioplegic solutions. J. of Thoracic and Cardiovascular Surgery 93(2):309-311.
Lianos, E.A., et al. (1983) Glomerular prostaglandin and thromboxane synthesis in rat nephrotoxic serum nephritis. J. Clin. Invest. 72:1439-1448.
Maguire, E. and Wallis, R. (1983) In vivo redirection of prostaglandin endoperoxides into 6-keto PGF.sub.1.alpha. formation by thromboxane synthetase inhibitors in the rat. Thrombosis Research 32:15-27.
Matheson, I., et al. (1975) The quenching of singlet oxygen by amino acids and proteins. Photochemistry and Photobiology 21:165-171.
Miller, D. et al. (1984) CT of the liver and spleen with EOE-13: review of 225 examinations. Am. Jour. of Rad. 143:235-243.
Needleman, P., et al. (1977) Thromboxane synthetase inhibitors as pharmacological tools: differential biochemical and biological effects on platelet suspensions. Prostaglandins 14(5):897-907.
Needleman, P., et al. (1979) Platelet and blood vessel arachidonate metabolism and interactions. J. Clin. Invest. 63:345-349.
Needleman, P., et al. (1977) Application of imidazole as a selective inhibitor of thromboxane synthetase in human platelets. Proc. Natl. Acad. Sci. 74(4):1716-1720.
Nilsson, K. et al. (1976) Contraction of glycerol extracted fibres of smooth muscle by acetylcholine and imidazole in the presence of a Ca-binding microsomal fraction from rabbit colon. Acta Physiol. Scand. 98:407-411.
Ogletree, M., et al. (1985) Pharmacological actions of SQ 29,548, a novel selective thromboxane antagonist. J. of Pharmacol. and Exper. Therapeutics 234(2):435-441.
Okegawa, T., et al. (1983) Endotoxin induces chronic prostaglandin and thromboxane synthesis from ureter-obstructed kidneys: role of inflammatory cells. J. of Pharmacology and Experimental Therapeutics 225(1):213-218.
Parkhouse, W., et al. (1985) Buffering capacity of deproteinized human vastus lateralis muscle. J. Appl. Physiol. 58(1):14-17.
Patterson, G., et al. (1985) Effects of imidazole and indomethacin on fluid balance in isolated sheep lungs. J. Applied Physiol. 58(3):892-898.
Purkerson, M., et al. (1985) Inhibition of thromboxane synthesis ameliorates the progressive kidney disease of rats with subtotal renal ablation. Proc. Natl. Acad. Sci. USA 82:193-197.
Redondo, J., et al. (1986/1987) Potentiation of interleukin-2 activity by levamisole and imidazole. Immunology Letters 14:111-116.
Riess, J. et al. (1987) Design, synthesis and evaluation of fluorocarbons and surfactants for in vivo applications new perfluoroalkylated polyhydroxylated surfactants. Int'l Symposium on Blood Substitutes, Montreal, May 1987.
Riess, J. (1984) Reassessment of criteria for the selection of perfluorochemicals for second-generation blood substitutes: analysis of structure/property relationships. Artificial Organs 8(1):44-56.
Saito, H., et al. (1984) Effects of a selective thromboxane A.sub.2 synthetase inhibitor on immune complex glomerulonephritis. Nephron 36:38-45.
Schirmer, W., et al. (1987) Effects of ibuprofen, indomethacin, and imidazole on survival in sepsis. Current Surgery Mar.-Apr. 102-105.
Tai, H.-H. and B. Yuan (1978) On the inhibitory potency of imidazole and its derivatives on thromboxane synthetase. Biochem. Biophys. Res. Commun. 80(1):236-242.
Zipser, R., et al. (1980) Exaggerated prostablandin and thromboxane synthesis in the rabbit with renal renal vein constriction. Circulation Research 47(2):231-237.

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