Prophylactic and therapeutic methods for treating interleukin-me

Details Prophylactic and therapeutic methods for treating interleukin-me Prophylactic and therapeutic methods for treating interleukin-me

1991-12-16

1994-01-11

Chan, Y. Christina

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 9, 514870, 514922, 530317, 530321, 424 852, A61K 3702, C07K 764

Patent

active

052781437

ABSTRACT:
Unique methods for treating interleukin-mediated edemas in living subjects are provided comprising administering an effective amount of a composition selected from the group consisting of phallotoxins, phallotoxin analogues, antamanide, or an antamanide analogue to the subject. The methods offer prophylactic and therapeutic modes of treatment for both localized and systemic interleukin-mediated edemas. The compositions of choice may be applied topically or given parenterally; and may be employed with other diverse agents for treatment of both inflammatory and non-inflammatory edemas.

REFERENCES:
patent: 4690915 (1987-09-01), Rosenberg
Rudinger, Peptide Hormones, Parsons (Ed.) U. Park Press, Baltimore, pp. 1-7 (1976).
Doukas et al., Blood, vol. 69, No. 6 pp. 1563-1569 (Jun. 1987).
Frimmer, Chem. Abstracts, vol. 71, No. 99937m (1969).
Wieland et al., Crit. Rev. Biochem. vol. 5, pp. 185-260 (1978).
Welbourn et al., J. Appl. Physiol. 70: 1364-1368 (1991).

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