Propargylic and allenic sulfones

Details Propargylic and allenic sulfones Propargylic and allenic sulfones

1990-01-26

1993-08-17

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Sulfur containing

568 32, 568 34, C07C31500

Patent

active

052371018

ABSTRACT:
Propargylic and allenic sulfones are disclosed having the ability to selectively cleave nucleic acids, especially deoxyribonucleic acid. Such compositions are capable of being synthetically modified to effect cleavage at selected, sequenced sites on nucleic acids.

REFERENCES:
Nicolaou, et al "A New Class of DNA-Cleaving Compounds" Angew. Chem. 101(9) pp. 1255-1257 (1989).
Yakovlev, et al "Disulfone Formation in the Reaction of Sodium Arenesulfinates with 4-Chloro-2-Butyn-1-ol" Zh. Obshch. Khim 57(1) pp. 237-238 (1987) Sec Chem. Abstr. vol. 107: 197678j, and p. 237.

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