Propargylethoxyamino nucleotides

Details Propargylethoxyamino nucleotides Propargylethoxyamino nucleotides

1996-08-13

1998-10-13

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 263, 536 266, 536 267, 536 2674, 536 268, 536 271, 536 2713, 536 2721, 536 276, 536 278, 536 2781, 536 281, 536 283, 536 284, 536 2853, 536 2854, C07H 1900

Patent

active

058213562

ABSTRACT:
Propargylethoxyamino nucleosides are disclosed having the structure ##STR1## wherein R.sub.1 and R.sub.2 are --H, lower alkyl, or label; B is a 7-deazapurine, purine, or pyrimidine nucleoside base; W.sub.1 is --H or --OH; W.sub.2 is --OH or a moiety which renders the nucleoside incapable of forming a phosphodiester bond at the 3'-position; and W.sub.3 is --PO.sub.4, --P.sub.2 O.sub.7, --P.sub.3 O.sub.10, phosphate analog, or --OH. Additionaly, a primer extension method is provided employing the above propargylethoxyamino nucleosides.

REFERENCES:
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patent: 5047519 (1991-09-01), Hobbs, Jr. et al.
patent: 5151507 (1992-09-01), Hobbs, Jr. et al.
patent: 5171534 (1992-12-01), Smith et al.
patent: 5188934 (1993-02-01), Menchen et al.
patent: 5366860 (1994-11-01), Bergot et al.
Livak et al., "Detectiton of single base differences using biotinylated nucleotides with very long linker arms," Nucleic Acids Research 20(18):4831-4837 (Aug. 12, 1992).
Kornher et al., "Mutation detection using nucleotide analogs that alter electrophoretic mobility," Nucleic Acids Research (17(19) (1989).

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