Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – N-c doai
Reexamination Certificate
2007-02-23
2009-12-01
Zucker, Paul A (Department: 1621)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
N-c doai
C560S162000, C560S163000, C514S478000
Reexamination Certificate
active
07625946
ABSTRACT:
This invention provides compounds having the structure:wherein R1is methyl and R2is H, or R1is ethyl and R2is hydroxymethyl;R3is H or propargyl; andR4is either H or t-butyloxycarbonyl;or an enantiomer or a pharmaceutically acceptable salt thereof. This invention further provides the use of a therapeutically effective amount of such compounds to treat a subject afflicted with a psychiatric disorder, Parkinson's disease, Alzheimer's disease, dementia, or a neurological disorder.
REFERENCES:
patent: 2573645 (1951-10-01), Kerwin et al.
patent: 2916490 (1959-12-01), Schenck et al.
patent: 2982783 (1961-05-01), Schenck et al.
patent: 3060091 (1962-10-01), Witkin
patent: 3123642 (1964-03-01), Temple et al.
patent: 3178478 (1965-04-01), Huebner et al.
patent: 3201470 (1965-08-01), Huebner et al.
patent: 3253037 (1966-05-01), Huebner et al.
patent: 3308157 (1967-03-01), Robertson et al.
patent: 3507962 (1970-04-01), Taylor
patent: 3513240 (1970-05-01), Bernardus et al.
patent: 3513244 (1970-05-01), Gittos et al.
patent: 3637740 (1972-01-01), Sarges
patent: 3704323 (1972-11-01), Krapcho
patent: 3709996 (1973-01-01), Gittos et al.
patent: 3751420 (1973-08-01), Hauck et al.
patent: 3804898 (1974-04-01), Panneman
patent: 3886168 (1975-05-01), Himmele et al.
patent: 3903297 (1975-09-01), Youdim et al.
patent: 3991207 (1976-11-01), Sarges et al.
patent: 4029731 (1977-06-01), Sarges
patent: 4096173 (1978-06-01), Molloy
patent: 4128666 (1978-12-01), Bondinell et al.
patent: 4132737 (1979-01-01), Molloy
patent: 4134997 (1979-01-01), Cannon et al.
patent: 4172093 (1979-10-01), Göransson-Dahlander et al.
patent: 4632939 (1986-12-01), Beedle et al.
patent: 4638001 (1987-01-01), Kuhla et al.
patent: 4788130 (1988-11-01), Oshiro et al.
patent: 4792628 (1988-12-01), Oshiro et al.
patent: 4826875 (1989-05-01), Chiesi
patent: 4833273 (1989-05-01), Goel et al.
patent: 4873241 (1989-10-01), Napier et al.
patent: 4948807 (1990-08-01), Rosin et al.
patent: 5011995 (1991-04-01), Pugin et al.
patent: 5071875 (1991-12-01), Horn et al.
patent: 5118704 (1992-06-01), Minaskanian et al.
patent: 5134147 (1992-07-01), Peglion et al.
patent: 5153225 (1992-10-01), Schohe et al.
patent: 5189045 (1993-02-01), Peglion et al.
patent: 5196583 (1993-03-01), Yamada et al.
patent: 5225596 (1993-07-01), Carlsson et al.
patent: 5242919 (1993-09-01), Oshiro et al.
patent: 5273974 (1993-12-01), Goto et al.
patent: 5286747 (1994-02-01), Arvidsson et al.
patent: 5378729 (1995-01-01), Kohn et al.
patent: 5387612 (1995-02-01), Youdim et al.
patent: 5389687 (1995-02-01), Schaus et al.
patent: 5401758 (1995-03-01), Atwal et al.
patent: 5453446 (1995-09-01), Youdim et al.
patent: 5457133 (1995-10-01), Youdim et al.
patent: 5486541 (1996-01-01), Sterling et al.
patent: 5516943 (1996-05-01), Gao et al.
patent: 5519061 (1996-05-01), Youdim et al.
patent: 5532415 (1996-07-01), Youdim et al.
patent: 5569669 (1996-10-01), Guillaumet et al.
patent: 5576353 (1996-11-01), Youdim et al.
patent: 5602176 (1997-02-01), Enz
patent: 5639913 (1997-06-01), Lidor et al.
patent: 5646188 (1997-07-01), Gilad et al.
patent: 5654301 (1997-08-01), Kohn et al.
patent: 5668181 (1997-09-01), Youdim et al.
patent: 5708018 (1998-01-01), Haadsma-Svensson et al.
patent: 5744500 (1998-04-01), Youdim et al.
patent: 5786390 (1998-07-01), Youdim et al.
patent: 5844003 (1998-12-01), Taton et al.
patent: 5877218 (1999-03-01), Herzig et al.
patent: 5877221 (1999-03-01), Cohen et al.
patent: 5880159 (1999-03-01), Herzig et al.
patent: 5891923 (1999-04-01), Youdim et al.
patent: 5914349 (1999-06-01), Cohen et al.
patent: 5994408 (1999-11-01), Cohen et al.
patent: 6251938 (2001-06-01), Chorev et al.
patent: 6303650 (2001-10-01), Chorev et al.
patent: 6316504 (2001-11-01), Youdim et al.
patent: 6462222 (2002-10-01), Chorev et al.
patent: 6528685 (2003-03-01), Cohen et al.
patent: 6538025 (2003-03-01), Chorev et al.
patent: RE39616 (2007-05-01), Chorev et al.
patent: 2002/0142969 (2002-10-01), Jeschke et al.
patent: 2004/0010038 (2004-01-01), Blaugrund et al.
patent: 2006/0189685 (2006-08-01), Caciularu et al.
patent: 2006/0189819 (2006-08-01), Bahar
patent: 2006/0276537 (2006-12-01), Goren et al.
patent: 2007/0135518 (2007-06-01), Weinstock-Rosin
patent: 2007/0232691 (2007-10-01), Goren
patent: 0436492 (1991-10-01), None
patent: 0664291 (1993-10-01), None
patent: 0614888 (1994-02-01), None
patent: 0538134 (1997-03-01), None
patent: 0951284 (2003-10-01), None
patent: 0852735 (1960-11-01), None
patent: 1003686 (1965-09-01), None
patent: 1022838 (2004-07-01), None
patent: 002155 (1991-03-01), None
patent: 9100724 (1991-01-01), None
patent: 9311761 (1993-06-01), None
patent: 9422495 (1994-10-01), None
patent: 9504027 (1995-02-01), None
patent: 9511016 (1995-04-01), None
patent: 9518617 (1995-07-01), None
patent: 9602524 (1996-02-01), None
patent: 9637199 (1996-11-01), None
patent: 9712583 (1997-04-01), None
patent: 9802152 (1998-01-01), None
patent: 9826775 (1998-06-01), None
patent: 9827055 (1998-06-01), None
patent: 03/072055 (2003-09-01), None
patent: 2006091656 (2006-08-01), None
patent: 2006091836 (2006-08-01), None
patent: 2006130726 (2006-12-01), None
patent: 2007070425 (2007-06-01), None
patent: 2007087029 (2007-08-01), None
patent: 2007100583 (2007-09-01), None
Sterling et al. J. Med. Chem. 2002, vol. 45, pp. 5260-5279.
Speiser et al. abstract of: Pharmacology (berl), Apr. 14, 2005.
The Merck Manual of Diagnosis and Therapy, (Berkow et al., eds., Merck Sharp & Dohme Research Laboratories, 15thed., 1987) 1054-1055.
The Merck Manual of Diagnosis and Tehrapy, (Berkow et al., eds., Merck Sharp & Dohme Research Laboratories, 15thed., 1987) 1054-1055.
The Parkinson Study Group, Effect of Deprenyl on the Progressino of Disability in Early Parkinson's Disease:New Eng. J. Med. (1989) 321(10): 1364-1371.
The Parkinson Study Group, “Effects of Tocopherol and Deprenyl on the Progression of Disability in Early Parkinson's Disease” New Eng. J. Med. (1993) 328(3):176-183.
Chemical Abstracts Service (Columbus, Ohio) Registry No. 209394-46-7.
Armstrong et al., (1990) “Acylation Effects on Chiral Recognition of Racemic Amines and Alcohols by New Polar and Non-Polar Cyclodextrin Derivative Gas Chromatographic Phases”J. Chromatography502-154-159.
Askin et al., (1992) “Highly Diastereoselective Alkylations of Chiral Amide Enolates: New Routes to Hydroxyethylene Dipeptide Isotere Inhibitors of HIV-1 Protease”,J. Org. Chem. 57(10): 2771-2773.
Baker et al., (1980) “Synthesis of Decahydrocyclopentacyclo-octene Derivatives via Intramolecular Photocycloaddition of Δα,β—Butenolides and Reductive Cleavage”,J. Chem. Soc. Chem. Comm. 23: 1011-1012.
Barton et al., (1988) “Reductive Formylation of Oximes; An Approach to the Synthesis of Vinyl Isonitriles”,Tetrahedron Letters29(27): 3343-3346.
Barker et al., (1995) “Principles of Ambulatory Medicine”,Williams&Wilkins4:1240-1257.
Bentue-Ferrer et al. (1996)CNS Drugs6:217.
Boar et al., (1975) “A Simple Synthesis of Enamides from Ketoximes”,J. Chem. Soc. Perkins I1237-1241.
Boltshauser et al., (2002) “Vanishing White Matter and Ovarian Dysgenesis in an Infant with Cerebro-oculo-facio-skeletal Phenotype”,Neuropediatrics33(2):57-6205.
Brettel et al., (1988) “Synthesis of Enamides”J. Chem. Soc. Perkins Trans. I2185-2193.
Burk et al., “A Three-Step Procedure for Asymmetric Catalytic Reductive Amidation of Ketones”,J. Org. Chem. (1998) 63: 6084-6085.
Chorvat et al., (1995) “Acetycholine Release Enhancing Agents: Potential Therapeutics For Alzheimer's Disease”,Drugs of the Future20(11):1145-1162.
Chrisp et al., (1991) “A Review of its Pharmacology, Symptomatic Benefits and Protective Potential in Parkinson's Disease”Drugs&Aging, 1:228-247.
Chumpradit, S. et al., (1993)J. Med. Chem. 36:4308.
Chumpradit, S. et al., (1995)J. of Labelled Compounds&Radiopharmaceuticals1051-1062 Abstract only.
Cooper et al., (1993), “Alzheimer's Disease Drug T
Cohen Bronka
Gottlieb Hugo
Herzig Yaacov
Lerner David
Miskolczi Istvan
Valenrod Yevegeny
Winston & Strawn LLP
Yissum Research Development Company of the Hebrew University of
Zucker Paul A
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