Propanolol antigen conjugates and antibodies

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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23230B, 424 12, 424 85, 435188, 260112R, 260121, 564349, C12Q 166, C12N 996, A61K 3900, C07G 700

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active

042411777

ABSTRACT:
Compounds are provided which can be used in the preparation of reagents useful for quantitatively determining the presence of .beta.-adrenergic blocking agents. These compounds contain a derivative of the blocking agent which is linked to an antigen or enzyme, the antigen conjugates being useful for preparing antibodies, and the enzyme conjugates being useful as detectors in an immunoassay as well. Additionally carboxylic acids, esters and aldehydes which are derivatives of the blocking agents are provided which are useful in preparing the above conjugates.

REFERENCES:
patent: 3337628 (1967-08-01), Crowther et al.
patent: 3690834 (1972-09-01), Goldstein et al.
patent: 3817837 (1974-06-01), Rubenstein et al.
patent: 3878187 (1975-04-01), Schneider
patent: 4026879 (1977-05-01), Spector
patent: 4070492 (1978-01-01), Spector
Smith, "Manufacture of propanolamine derivatives", Chem. Abstracts, vol. 67, No. 21, p. 9389 (1967) abs. No. 99907u.
Crowther, et al., "Naphthyl ethanol derivatives", Chem. Abstracts, vol. 67, No. 21, p. 9389 (1967) abs. No. 99908v.

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