Propanolaminomethyltetralines, their preparation and...

Details Propanolaminomethyltetralines, their preparation and... Propanolaminomethyltetralines, their preparation and...

2006-10-03

2006-10-03

Davis, Brian (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S099000, C564S399000, C548S217000, C544S105000, C514S230500, C514S375000, C514S605000, C514S647000

Reexamination Certificate

active

07115780

ABSTRACT:
The invention concerns compounds of formula (I), wherein A is a group of formula (a) or (b), wherein: R represents a hydrogen or halogen atom, a —S(O)z(C1–C4)Alk wherein z is 0, 1 or 2, a —NHSO2(C1–C4)Alk, —SO2NH(C1–C4)Alk, —NHSO2—(C1–C4)Alk-phenyl or —NHSO2-phenyl group, said phenyl capable of bearing a halogen atom, a (C1–C4)Alk group or a (C1–C6)alkoxy group; R1represents a hydrogen atom or a —(C1–C4)Alk, —CO(C1–C4)Alk, —(C1–C4)Alk-phenyl or —CO-phenyl group, said phenyl capable of bearing a halogen atom or a —(C1–C4)Alk or (C1–C6)alkoxy group; R2is a hydrogen atom, a —SO2(C1–C4)Alk, —SO2—(C1–C4)Alk-phenyl, —SO2-phenyl group, or a —(C1–C4)Alk group; X completes a saturated or unsaturated cycle of 5 to 8 atoms, capable of bearing one or two —(C1–C4)Alk groups and/or two carbonyl groups; R3and R′3represent each independently a hydrogen or halogen atom, a —(C1–C6)Alk, hydroxy, —CN, —(C1–C6)alkoxy, —COR4or Y—CR8R9—COR4group; Y represents O or CH2; R4represents a hydroxy, (C1–C6)alkoxy or —NR5R6group; R5and R6independently represent a hydrogen atom, a —(C1–C4)Alk, group, aryl or heteroaryl optionally substituted by a R7group, aralkyl or heteroaralkyl optionally substituted by a R7group; or R5and R6, with the nitrogen atom which bears them, form a saturated or unsaturated cycle of 5 to 7 atoms optionally substituted by a R7group; and R7represents a hydrogen or halogen atom, a hydroxy, —(C1–C4)Alk, —(C1–C6)alkoxy, —NH(C1–C4)Alk, —N(C1–C4)Alk2, —COO(C1–C4)Alk, aralkyl or heteroaryl group; R8and R9independently represent a hydrogen atom or a —(C1–C4)Alk group; their salts or solvates, the pharmaceutical compositions containing them, a method for preparing them and synthesis intermediates

REFERENCES:
patent: 4004028 (1977-01-01), Kaiser
patent: 5194450 (1993-03-01), McDermed et al.
patent: 5254595 (1993-10-01), Guzzi et al.
patent: 2004/0034070 (2004-02-01), Barzaghi et al.
patent: 0 375 560 (1989-12-01), None
patent: WO 99 51564 (1999-10-01), None

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