Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-06-17
1993-08-17
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514439, 514452, 549 35, 549369, A61K 31385, A61K 3139, A61K 31335
Patent
active
052369471
ABSTRACT:
The present invention relates to propanamines of general formula (I) ##STR1## in which: R1 is a phenyl radical optionally mono-, di- or trisubstituted in an identical or different manner with halogen atoms, or lower alkyl, lower haloalkyl or lower alkoxy radicals;
R2 is a lower alkyl radical,
R3 and R4 are a hydrogen atom or a lower alkyl, lower alkenyl or lower cycloalkyalkyl radical,
R5 is a 5-to 7-membered cycloalkyl radical or a phenyl radical, and
W represents a heterocycle .dbd.C[Q--(CH.sub.2).sub.n --Q] in which Q is an oxygen or sulfur atom and n is 2 or 3,
and their acid addition salts with pharmaceutically acceptable acids. The invention also relates to antidiarrheal pharmaceutical compositions comprising the claimed propanamines.
REFERENCES:
patent: 3182084 (1965-05-01), Wilson et al.
patent: 3714159 (1973-01-01), Janssen et al.
Calvet Alain
Grouhel Agnes
Jacobelli Henri
Junien Jean-Louis
Pascaud Xavier
Jouveinal S.A.
Owens A. A.
Rotman Alan L.
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