Propagation and/or derivation of embryonic stem cells

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S405000

Reexamination Certificate

active

06875608

ABSTRACT:
Embryonic stem (ES) cells are cultured in the presence of a compound which selectively inhibits propagation or survival of cells other than ES cells. The ES cells have not been genetically altered. Instead, the compound inhibits a signalling pathway which is essential for propagation of differentiated cells but is not essential for propagation of ES cells—hence ES cells are selectively maintained in the culture

REFERENCES:
patent: 6146888 (2000-11-01), Smith et al.
patent: WO0015764 (2000-03-01), None
patent: WO 9730151 (1997-08-01), None
Niwa, Jul. 1, 1998, Genes and Development, vol. 12, p. 2048-2060.*
Hitoshi Niwa et al., “Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3,”Genes&Development, vol. 12 (No. 13):2048-2060 (Jul. 1, 1998).
D.T. Dudley et al., “A Synthetic Inhibitor of the Mitogen-Activated Protein Kinase Cascade,”Proceedings of the National Academy of Sciences of USA, vol. 92:7686-7689 (Aug. 1995).
T. Burdon et al., “Suppression of SHP-2 and ERK Signalling Promotes Self-Renewal of Mouse Embryonic Stem Cells,”Developmental Biology, vol. 210:30-43 (Jun. 1, 1999).
T. Burdon et al., “Signaling Mechanisms Regulating Self-Renewal and Differentiation of Pluripotent Embryonic Stem Cells,”Cells Tissues Organs, vol. 165 (No. 3-4): 131-143, (1999).
International Search Report.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Propagation and/or derivation of embryonic stem cells does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Propagation and/or derivation of embryonic stem cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Propagation and/or derivation of embryonic stem cells will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3370250

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.