Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Reexamination Certificate
2008-05-13
2008-05-13
Wilson, Michael C. (Department: 1632)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
C435S455000
Reexamination Certificate
active
07371573
ABSTRACT:
Embryonic stem (ES) cells are cultured in the presence of a compound which selectively inhibits propagation or survival of cells other than ES cells. The ES cells have not been genetically altered. Instead, the compound inhibits a signalling pathway which is essential for propagation of differentiated cells but is not essential for propagation of ES cells—hence ES cells are selectively maintained in the culture.
REFERENCES:
patent: 6146888 (2000-11-01), Smith et al.
patent: WO 94/24301 (1994-09-01), None
patent: WO A-94/24274 (1994-10-01), None
patent: WO 97/30151 (1997-08-01), None
patent: WO 00/15764 (2000-03-01), None
Nichols, Exp. Cell Research, 1994, vol. 215, p. 237-239.
Bettina, Neurochemistry International, Jun. 2005, vol. 46, No. 7, p. 513-521, abstract only.
Yao, Zhongguo Zhongliu Linchuang, 2005, vol. 43, No. 5, p. 290-291, abstract only.
Seo Geom-Seog, Free radical biology & medicine, May 1, 2006, vol. 40, No. 9, p. 1502-1512, abstract only.
MGI webpage labeled “Search Results” listing MEK, MEK1 and MEK2 as separate proteins, no date.
Niwa (Jul. 1, 1998, Genes & Development, vol. 12, p. 2048-2060).
Burdon et al., “Signaling Mechanisms Regulating Self-Renewal and Differentiation of Pluripotent Embyronic Stem Cells,”Cells Tissues Organs, vol. 165 (No. 3-4): 131-143, (1999).
Burdon et al., “Suppression of SHP-2 and ERK Signalling Promotes Self-Renewal of Mouse Embryonic Stem Cells,”Developmental Biology, vol. 210:30-43 (Jun. 1999).
Dudley et al., “A Synthetic Inhibitor of the Mitogen-Activated Protein Kinase Cascade,”Proceedings of the National Academy of Sciences of USA, vol. 92:7686-7689 (Aug. 1995).
Fukada, T.H. et al., Two Signals are Necessary for Cell Proliferation Induced by a Cytokine Receptor GP 130: Involvement of Stat3 in Anti-Apoptosis,Immunity, vol. 5(5):449-460 (1996).
Niwa et al., “Self-renewal of Pluripotent Embryonic Stem Cells is Mediated Via Activation of STAT3,”Genes and Development, vol. 12 (No. 13):2048-2060 (Jul. 1, 1998).
Savatier et al., “Withdrawal of Differentiation Inhibitory Activity/Leukemia Inhibitory Factor Up-Regulates D-Type Cyclins and Cyclin-Dependent Kinase Inhibitors in Mouse Embryonic Stem Cells,”Oncogene, vol. 12(2):309-322 (1996).
Atkins et al., “The MAPK Cascade is Required for Mammalian Associative Learning,”Nature Neuroscience1(7):602-609 (1998).
Ciruela et al., “Identification of MEK1 as a Novel Target for the Treatment of Neuropathic Pain,”British Journal of Pharmacology138:751-756 (2003).
Cunnick et al., “Role of Tyrosine Kinase Activity of Epidermal Growth Factor Receptor in the Lysophosphatidic Acid-stimulated Mitogen-activated Protein Kinase Pathway,”The Journal of Biological Chemistry273(23):14468-14475 (1998).
Daum et al., “Pervanadate Inhibits Mitogen-activated Protein Kinase Kinase-1 in a p38MAPK-dependent Manner,”FEBS Letters427:271-274 (1998).
Downey et al., “Chemotactic Peptide-induced Activation of MEK-2, the Predominant Isoform in Human Neutrophils,”The Journal of Biological Chemistry271 (35):21005-21011 (1996).
Duesbery et al., “Proteolytic Inactivation of MAP-Kinase-Kinase by Anthrax Lethal Factor,”Science280:734-737 (1998).
Favata et al., “Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase,”The Journal of Biological Chemistry273(29):18623-18632 (1998).
Fourcin et al., “gp130 Transducing Receptor Cross-linking is Sufficient to Induce Interleukin-6 Type Responses,”The Journal of Biological Chemistry271(20):11756-11760 (1996).
Horiuchi et al., “Competitive Inhibition of MAP Kinase Activation by a Peptide Representing the αcHelix of ERK,”Biochemistry37:8879-8885 (1998).
Molden et al., “A Kaposi's Sarcoma-associated Herpesvirus-encoded Cytokine Homolog (vIL-6) Activates Signaling through the Shared gp130 Receptor Subunit,”The Journal of Biological Chemistry272(31):19625-19631 (1997).
Pennica et al., “Cardiotrophin-1: Biological Activities and Binding to the Leukemia Inhibitory Factor Receptor/gp130 Signaling Complex,”The Journal of Biological Chemistry270(18):10915-10922 (1995).
Sebolt-Leopold et al., “Blockade of the MAP Kinase Pathway Suppresses Growth of Colon Tumors In Vivo,”Nature Medicine5(7):810-816 (1999).
Taga et al., “Functional Inhibition of Hematopoietic and Neurotrophic Cytokines by Blocking the Interleukin 6 Signal Transducer gp130,”Proc. Natl. Acad. Sci. USA89:10998-11001 (1992).
Tresini et al., “A Phosphatidylinositol 3-Kinase Inhibitor Induces a Senescent-Like Growth Arrest in Human Diploid Fibroblasts,”Cancer Res.58(1):1-4 (1998) (abstract).
Williams et al., “Ro 09-2210 Exhibits Potent Anti-Proliferative Effects on Activated T Cells by Selectively Blocking MKK Activity,”Biochemistry37:9579-9585 (1998).
Yawata et al., “Structure—Function Analysis of Human IL-6 Receptor: Dissociation of Amino Acid Residues Required for IL-6-binding and for IL-6 Signal Transduction through gp130,”The EMBO Journal12(4):1705-1712 (1993).
Zhang et al., “Synthesis and Structure—Activity Relationships of 3-Cyano-4-(phenoxyanilino)quinolines as MEK (MAPKK) Inhibitors,”Bioorganic&Medicinal Chemistry Letters10:2825-2828 (2000).
Zhao et al., “Resorcylic Acid Lactones: Naturally Occurring Potent and Selective Inhibitors of MEK,”J. Antibiot.52(12):1086-1094 (1999) (abstract).
Burdon Thomas Grant
Smith Austin Gerard
Finnegan Henderson Farabow Garrett & Dunner L.L.P.
University of Edinburgh
Wilson Michael C.
LandOfFree
Propagation and/or derivation of embryonic stem cells does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Propagation and/or derivation of embryonic stem cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Propagation and/or derivation of embryonic stem cells will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2812517