Propagatable, new combinant cells for cellular replacement thera

Details Propagatable, new combinant cells for cellular replacement thera Propagatable, new combinant cells for cellular replacement thera

1988-12-27

1992-12-29

Saunders, David

Drug, bio-affecting and body treating compositions

Extract, body fluid, or cellular material of undetermined...

424556, 424572, 435 1, 4351722, 43524026, 604 48, 935 52, 935 59, 935 89, 935 93, A01N 100, A61K 3512, C12N 1502

Patent

active

051750040

ABSTRACT:
A method for creating a propagatable, new combinant cell with differentiated function to replenish dwindling number of similar cells in diseased subjects. The new combinant cell is obtained by 1) removing a nucleated cell, which is of the same differentiative phenotype as the diseased cells, from a subject and isolating therefrom a karyoplast, 2) isolating from a source other than said subject a proliferation-prone cell which is of the same differentiative phenotype or which is predestined to become the same phenotype as the diseased cells and isolating therefrom a cytoplast, 3) fusing the cytoplast and karyoplast to form a propagatable, new combinant cell, 4) propagating the combinant cell in culture, and 5) transplanting the combinant cells into said subject. In another embodiment the karyoplast donor is histocompatible to said subject. In yet another embodiment a whole cell is used in lieu of a karyoplast for fusion with the cytoplast.

REFERENCES:
patent: 4195125 (1980-03-01), Wacker
patent: 4439521 (1984-03-01), Archer et al.
patent: 4645669 (1987-02-01), Reid
patent: 4963489 (1990-10-01), Naughton et al.
M. J. Narasimhan et al., Int. Cong. Ser.-Excerpta Med. 413, 521-528, 1977.
Hightower et al., in Snay et al., (EDS.), Techniques in Somatic Cell Genetics, Plenum Press, New York, 1982, pp. 255-267.
Narasimhan et al., Chem. Abs. 89, 22072q, 1978.
Wacker et al., Chem. Abs., 86, 118951q, 1977.
Veomett et al., Proc. Natl. Acad. Sci., USA, 71, 1999-2002, 1974.

Affiliated with

Also associated with

Rating

Propagatable, new combinant cells for cellular replacement thera does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Propagatable, new combinant cells for cellular replacement thera, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Propagatable, new combinant cells for cellular replacement thera will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1885928