Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1996-07-26
1998-06-09
Huff, Sheela
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 13, 514 14, 514 15, 514 16, 514 17, 514 18, 514 19, 530324, 530325, 530326, 530327, 530328, 530329, 530330, 530331, 530350, A61K 3800, C07K 500, C07K 700, C07K 1700
Patent
active
057634025
ABSTRACT:
A method of promoting or inhibiting spermatogenesis, said method comprising administering to a male an effective amount of PACAP, a PACAP agonist, a PACAP antagonist, PC4, a PC4 agonist, or a PC4 antagonist.
REFERENCES:
patent: 5128242 (1992-07-01), Arimura et al.
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Shioda et al, Endocrinology vol. 135 p. 818, 1994.
Akira Arimura, "Receptors for Pituitary Adenylate Cyclase-Activating Polypeptide", TEM 3:288-294, 1992.
Arimura et al., "PACAP Functions as a Neutrotrophic Factor", Annals New York Academy of Sciences 228-243. (1992).
Akira Arimura, "Pituitary Adenylate Cyclase Activating Polypeptide (PACAP): Discovery and Current Status of Research", Regulatory Peptides 37:287-303, 1992.
Arimura et al., "Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) and its Receptors: Neuroendocrine and Endocrine Interaction", Frontiers In Neuroendocrinology 16:58-88, 1995.
Arimura et al., "Tissue Distribution of PACAP as Determined by RIA: Highly Abundant in the Rat Brain and Testes", Endocrinology 129:2787-2789, 1991.
Gottschall et al., "Characterization and Distribution of Binding Sites for the Hypothalamic Peptide, Pituitary Adenylate Cyclase-Activating Polypeptide", Endocrinology 127:272-277, 1990.
Heindel et al., "A Novel Hypothalamic Peptide, Pituitary Adenylate Cyclase Activating Peptide, Modulates Sertoli Cell Function in Vitro", Biology of Reproduction 47:800-806, 1992.
Miyata et al., "Isolation of a Neuropeptide Corresponding to the N-Terminal 27 Residues of the Pituitary Adenylate Cyclase Activating . . . ", Biochemical & Biophysical Research Communications 170:643-648, 1990.
Miyata et al., "Isolation of a Novel 38 Residue-Hypothalamic Polypeptide Which Stimulates Adenylate Cyclase In Pituitary Cells", Biochemical and Biophysical Research Communications 164:567-574, 1989.
Shivers et al., "Two High Affinity Binding Sites for Pituitary Adenylate Cyclase-Activating Polypeptide Have Different Tissue Distributions", Endocrinology 128:3055-2065, 1991.
Huff Sheela
The Administrators of the Tulane Educational Fund
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