Promotion of homologous DNA pairing by RecA-derived peptides

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 15 to 23 amino acid residues in defined sequence

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530300, C07K 1708, A61K 3810

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active

057314110

ABSTRACT:
A peptide having at least 15 consecutive amino acids of the amino acid sequence shown in SEQ ID NO:1 or conservative amino acid substitutions thereof. The peptide is capable of promoting pairing of a single-stranded DNA molecule and a double-stranded DNA molecule. The single-stranded DNA molecule is homologous to at least a portion of the double-stranded DNA molecule. The single-stranded DNA molecule and the double-stranded DNA molecule form a three-stranded DNA molecule.

REFERENCES:
patent: 4736866 (1988-04-01), Leder et al.
patent: 5460941 (1995-10-01), Camerini-Otero et al.
patent: 5510473 (1996-04-01), Camerini-Otero et al.
B. Alberts, et al. (1989), Molecular Biology Of The Cell, Second Edition, Garland Publishing, Inc., New York, p. 980.
C.R. Bartram, et al. (1983) "Translocation of c-abl Oncogene Correlates with the Presence of a Philadelphia Chromosome in Chronic Myelocytic Leukaemia", Nature, 306(17):277-280.
R.D. Camerini-Otero, et al. (1993) "Parallel DNA Triplexes, Homologous Recombination, and Other Homology-Dependent DNA Interactions", Cell, 73:217-223.
A.J. Clark, et al. (1965) "Isolation and Characterization of Recombination-Deficient Mutants of Escherichia coli K12", Proc. N. A. S., 53:451-459.
M.M. Cox (1993) "Relating Biochemistry to Biology: How the Recombinational Repair Function of RecA Protein is Manifested in Its Molecular Properties", BioEssays, 15(9):617-623.
J. Groffen, et al. (1984) "Philadelphia Chromosomal Breakpoints are Clustered within a Limited Region, bcr. on Chromosome 22", Cell, 36:93-99.
H. Hayatsu, et al. (1967) "The Selective Degradation of Pyrimidines in Nucleic Acids by Permanganate Oxidation", Biochem. And Biophys. Res. Communications, 29(4):556-561.
Th. Koller, et al. (1983) "Complexes of recA Protein with Single Stranded DNA" Mech. of DNA Replication and Recombination, 723-729.
S.C. Kowalczykowski, et al. (1994) "Homologous Pairing and DNA Strand-Exchange Proteins", Annu. Rev. Biochem., 63:991-1043.
R. Kurzrock, et al. (1987) "A Novel c-abl Protein Product in Philadelphia-Positive Acute Lymphoblastic Leukaemia" Nature, 325(12):631-635.
S.L. Mansour (1990) "Gene Targeting in Murine Embryonic Stem Cells: Introduction of Specific Alterations into the Mammalian Genome", GATA, 7(8):219-227.
A.M. Maxam, et al. (1977) "Sequencing End-Labeled DNA with Base-Specific Chemical Cleavages", Methods in Enzymology, 65:499-560.
A.I. Roca, et al. (1990) "The RecA Protein: Structure and Function", Biochemistry and Mol. Biology, 415-456.
R.M. Story, et al. (1992) "The Structure of the E. coli recA Protein Monomer and Polymer", Nature, 355:318-325.
R.M. Story, et al. (1993) "Structural Relationship of Bacterial RecA Proteins to Recombination Proteins from Bacteriophage T4 and Yeast", Science, 259:1892-1896.
I. Wong, et al. (1993) "A Double-Filter Method for Nitrocellulose-Filter Binding: Application to Protein-Nucleic Acid Interactions", Proc. Natl. Acad. Sci. USA, 90:5428-5432.
R.W. Woody, et al. (1985) "Circular Dichroism of Peptides", The Peptides, 7:15-114.
Maraboeuf et al 1995 J. Biol. Chem. 270(52):30927-30932.
Gardner et al 1995 Eur. J. Biochem. 233:419-425.
Voloshin et al 1996 Science 272:868-872.

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