Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-11-09
1999-06-29
Stanton, Brian R.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
536 241, 4353201, 435325, 435366, 435455, 435471, 435 701, C07H 2104, C12P 2106, C12N 1500, C12N 500
Patent
active
059167637
ABSTRACT:
This invention provides nucleic acid sequences for a VEGF receptor promoter, particularly for the Flt-1 promoter, expression vectors and recombinant host cells containing this promoter. It also provides methods for screening for drugs that regulate the transcriptional activity of the VEGF receptor promoter. Methods for endothelial-specific gene expression and treatment of disease, particularly by inhibiting angioigenesis, using novel gene constructs containing the VEGF receptor promoter are also provided. Transgenic animals having heterologous genes linked to the VEGF receptor promoter are also provided.
REFERENCES:
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Morishita Kaoru
Williams Lewis T.
Clark Deborah J. R.
Stanton Brian R.
The Regents of the University of California
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