Promoter deficient retroviral vector

Details Promoter deficient retroviral vector Promoter deficient retroviral vector

1987-04-27

1990-12-25

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

435 691, 435 701, 435 703, 4351721, 4351723, 4352523, 435320, 4352401, 935 22, 935 23, 935 32, 935 52, 935 57, C12P 2100, C12N 1500, C12N 700

Patent

active

049802895

ABSTRACT:
A recombinant retrovirus vector is disclosed. It is of the type having a normally replication incompetent retrovirus gene sequence with a foreign eukaryotic gene to be expressed. The retrovirus gene sequence is designed so as to be promoter deficient in the right side LTR. The vector can produce progeny virus from helper cells, which progeny can infect a eukaryotic host cell, form a provirus, and express the eukaryotic gene in the host cell. However, the provirus will then be defective in the retrovirus promoter, such that retrovirus RNA is not expressed from the provirus.

REFERENCES:
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