Promiscuous G-protein compositions and their use

Details Promiscuous G-protein compositions and their use Promiscuous G-protein compositions and their use

1997-06-19

1999-12-21

Achutamurthy, Ponnathapu

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435 4, 4351723, 435366, 436 63, C12N 510

Patent

active

060048085

ABSTRACT:
Disclosed are compositions and methods for their use, such as in identifying G-protein coupled receptors and ligands and compounds that modulate signal transduction. The compositions and methods employ promicuous G-proteins. Activation of the promiscous G-protein can be detected in a variety of assays, including assays in which activation is indicated by a change in fluorescence emission of a sample that contains the composition.

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