Prolonged storage of red blood cells

Details Prolonged storage of red blood cells Prolonged storage of red blood cells

1984-07-19

1986-04-29

Rosen, Sam

Chemistry: molecular biology and microbiology

Maintaining blood or sperm in a physiologically active state...

424101, A01N 102, A61K 3518

Patent

active

045857350

ABSTRACT:
The present invention discloses a hypotonic suspension medium and a method for prolonged storage of red blood cells at about 4.degree. C. The suspension medium comprises about 80-150 mM glucose, 30-80 mM mannitol, 6-90 mM potassium citrate, 1-5 mM adenine and 10-200 mM ammonium chloride or acetate in an aqueous solution having a pH of about 6.8 to 7.2 and an osmolarity of about 180-220 milli-osmolar. The suspension medium and the method of the present invention allow viable storage of red blood cells at about 4.degree. C. up to 125 days or more.

REFERENCES:
patent: 4061537 (1977-12-01), Seiler et al.
patent: 4356172 (1982-10-01), Nakao et al.
patent: 4476221 (1984-10-01), Kane et al.
Chem. Abstracts, vol. 91, 33536m, published 1979.
Chem. Abstracts, vol. 79, 112,107c, published 1973.

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