Prolonged release microcapsules and their production

Details Prolonged release microcapsules and their production Prolonged release microcapsules and their production

1986-12-11

1987-12-08

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

264 46, 424 85, 424457, 424497, 4284022, 514963, A61K 952, B01J 1302

Patent

active

047117826

ABSTRACT:
A microcapsule produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing said water-soluble drug and a drug retaining substance therefor and an oil layer containing a polymer substance, then thickening or solidifying said inner aqueous layer to a viscosity of not lower than about 5000 centiposes and finally subjecting the resulting emulsion to in water drying gives prolonged release of water-soluble drug.

REFERENCES:
patent: 3523906 (1970-08-01), Vrancken et al.
patent: 3691090 (1972-09-01), Kitajima et al.
patent: 3773919 (1973-11-01), Boswell et al.
patent: 4234571 (1980-11-01), Nestor et al.
patent: 4272398 (1981-06-01), Jaffe
patent: 4273920 (1981-06-01), Nevin
patent: 4652441 (1987-03-01), Okada et al.
Microcapsule, Industrial Technology Library 25, pp. 102-103 (1971).
Journal of the Chemical Society of Japan, vol. 72, pp. 493-499 (1969).
Journal of Bioengineering, vol. 1, pp. 25-32, 1976, Thomas M. S. Chang (McGill University).
Japanese Patent Application Publication No. 13703/1967, Shizuo Miyano, et al., (Fuji Photo Film).
The Pharmacopoeia of Japan, 10th Edition, 1981, English Version, Society of Japanese Pharmacopoeia, Yakuji Nippo, Ltd., 1981, pp. 16-21.

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