Prolonged release microcapsules

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert

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Details

424500, 424433, 424497, 424499, 4284022, 514 2, 514800, 514843, 514963, A61K 952, B01J 1302, A61F 200

Patent

active

049178938

ABSTRACT:
A microcapsule produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing said water-soluble drug and a drug retaining substance therefor and an oil layer containing a polymer substance, then thickening or solidifying said inner aqueous layer to a viscosity of not lower than about 5000 centiposes and finally subjecting the resulting emulsion to in water drying gives prolonged release of water-soluble drug.

REFERENCES:
patent: 3523906 (1970-08-01), Vrancken et al.
patent: 3645911 (1972-02-01), van Besauw et al.
patent: 3691090 (1972-09-01), Kitajima et al.
patent: 3773919 (1973-11-01), Boswell et al.
patent: 4234571 (1980-11-01), Nestor et al.
patent: 4272398 (1981-06-01), Jaffe
patent: 4273920 (1981-06-01), Nevin
patent: 4652441 (1987-03-01), Okada et al.
"Microcapsules Containing an Enzyme", Journal of the Chemical Society of Japan, vol. 72, pp. 493-499, (1969).
Chang, "Biodegradable Semipermeable Microcapsules Containing Enzymes, Hormones, Vaccines, and Other Biologicals", Journal of Bioengineering, vol. 1, pp. 25-32, (1976).
General Rules for Preparations, The Pharmacopoeia of Japan, Tenth Edition (1981) English Version: Society of Japanese Pharmacopoeia, (1982).
Microcapsule, Industrial Technology Library 25, pp. 102-103 (1971).
Japanese Patent Application Publication No. 13703/1967, Shizuo Miyano, et al. (Fuji Photo Film).

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