Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1987-09-30
1990-04-17
Terapane, John F.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424500, 424433, 424497, 424499, 4284022, 514 2, 514800, 514843, 514963, A61K 952, B01J 1302, A61F 200
Patent
active
049178938
ABSTRACT:
A microcapsule produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing said water-soluble drug and a drug retaining substance therefor and an oil layer containing a polymer substance, then thickening or solidifying said inner aqueous layer to a viscosity of not lower than about 5000 centiposes and finally subjecting the resulting emulsion to in water drying gives prolonged release of water-soluble drug.
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Chang, "Biodegradable Semipermeable Microcapsules Containing Enzymes, Hormones, Vaccines, and Other Biologicals", Journal of Bioengineering, vol. 1, pp. 25-32, (1976).
General Rules for Preparations, The Pharmacopoeia of Japan, Tenth Edition (1981) English Version: Society of Japanese Pharmacopoeia, (1982).
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Japanese Patent Application Publication No. 13703/1967, Shizuo Miyano, et al. (Fuji Photo Film).
Ogawa Yasuaki
Okada Hiroaki
Yashiki Takatsuka
Covert John M.
Takeda Chemical Industries Ltd.
Terapane John F.
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