Prolonged release microcapsule of a water-soluble drug

Details Prolonged release microcapsule of a water-soluble drug Prolonged release microcapsule of a water-soluble drug

1990-01-24

1991-10-29

Stoll, Robert L.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424426, 424497, 424499, 4284022, 514963, A61K 952, B01J 1312, A61F 200

Patent

active

050614924

ABSTRACT:
A microcapsule produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing said water-soluble drug and a drug retaining substance therefor and an oil layer containing a polymer substance, then thickening or solidifying said inner aqueous layer to a viscosity of not lower than about 5000 centiposes and finally subjecting the resulting emulsion to in water drying gives prolonged release of water-soluble drug.

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patent: 4849228 (1989-07-01), Yamamoto et al.
patent: 4917893 (1990-04-01), Okada et al.
Chang, "Biodegradable Semipermeable Microcapsules Containing Enzymes, Hormones, Vaccines, and Other Biologicals," Journal of Bioengineering, vol. 1, pp. 25-32, 1976.
The Pharmacopoeia of Japan, Tenth Edition, 1981, pp. 16-21.
Journal of the Chemical Society of Japan, vol. 72, 1969, pp. 493-499 (with translation).

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