Prolonged release drug tablet formulations

Details Prolonged release drug tablet formulations Prolonged release drug tablet formulations

1989-11-22

1992-03-17

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Food or edible as carrier for pharmaceutical

424451, 424452, 424457, 424458, 424461, 424464, 424465, 424466, 424468, 424469, 424470, 424484, 424488, 424489, 424494, 514960, A61K 914, A61K 4700

Patent

active

050967142

ABSTRACT:
A prolonged-release unit dosage formulation or pharmaceutical composition, preferably in tablet form, is described. The composition consists essentially of a gel-forming dietary fiber, a biologically-absorbable drug or other active therapeutic agent, and certain specific disintegrants, namely, a physiologically-acceptable edible acid and a mineral salt which releases a physiologically-acceptable gas upon ingestion, preferably carbon dioxide, e.g., a mineral carbonate or bicarbonate, and advantageously dextrose or like soluble sugar. The dietary fiber-containing composition, when compressed into a tablet together with the drug and the specific disintegrants, provides a unique and efficient prolonged-action drug-delivery system.

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