Prolonged-release drug tablet formulations

Details Prolonged-release drug tablet formulations Prolonged-release drug tablet formulations

1992-03-16

1994-03-08

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Food or edible as carrier for pharmaceutical

424464, 424465, 424466, 424468, 424469, 424485, 424488, 424489, 424494, 424495, 514356, 514777, 514781, 514960, 514782, A61K 916, A61K 922, A61K 4726, A61K 4736

Patent

active

052925188

ABSTRACT:
A prolonged-release unit dosage formulation or pharmaceutical composition, preferably in tablet form, is described. The composition consists essentially of a gel-forming dietary fiber, a biologically-absorbable drug or other active therapeutic agent, and a disintegrant, namely, a mineral salt which releases a physiologically-acceptable gas upon ingestion, preferably carbon dioxide, e g., a mineral carbonate or bicarbonate, and advantageously dextrose or like soluble sugar. A physiologically-acceptable acid may optionally be included in the composition to further facilitate disintegration. The dietary fiber-containing composition, when compressed into a tablet together with the drug and the specific disintegrants, provides a unique and efficient prolonged-action drug-delivery system.

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Council Report, "Dietary Fiber and Health," Journal of the American Medical Association, Jul. 28, 1989, vol. 262, No. 4, pp. 542-546.

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