Prolonged release drug dosage forms based on modified low viscos

Details Prolonged release drug dosage forms based on modified low viscos Prolonged release drug dosage forms based on modified low viscos

1984-04-02

1985-09-10

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

424 19, 424 35, 514781, 514964, A61K 922, A61K 926

Patent

active

045405662

ABSTRACT:
A carrier base material combined with a therapeutically active medicament and shaped and compressed to a solid unit dosage form having a controlled and prolonged release pattern upon administration, the carrier base material being a mixture of one or more nonionic cellulose ethers and an anionic surfactant, and wherein at least one of the cellulose ethers is a modified hydroxypropylmethylcellulose having a number average molecular weight of less than 50,000 and has been modified by successive or concurrent exposure to moisture and air.

REFERENCES:
patent: 3065143 (1962-11-01), Christenson et al.
patent: 3870790 (1975-03-01), Lowey et al.
patent: 4226849 (1980-10-01), Schor
patent: 4259314 (1981-03-01), Lowey
patent: 4264573 (1981-04-01), Powell et al.
patent: 4344934 (1982-08-01), Martin et al.
patent: 4369172 (1983-01-01), Schor et al.
patent: 4389393 (1983-06-01), Schor et al.
Daly et al, Int. J. Pharm., 18(1-2):201-205 (1984) The Effect of Anionic Surfactants on the Release of Chlorpheniramine Maleate from a Polymer Matrix Tablet.
Krycer et al., Powder Technol., 34(1):39-50 (1983) An Evaluation of Tablet Binding Agents.

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