Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills
Patent
1998-08-10
2000-09-19
Spear, James M.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Tablets, lozenges, or pills
424468, 424469, 424470, 424486, 424488, 5147722, 5147723, 514777, 514778, 514781, 514782, 514784, A61K 922, A61K 926
Patent
active
061208035
ABSTRACT:
The present invention is directed to an active agent dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of an active agent formulation to a fluid environment of use. The active agent dosage form is a polymer matrix that swells upon contact with the fluids of the stomach. A portion of the polymer matrix is surrounded by a band of insoluble material that prevents the covered portion of the polymer matrix from swelling and provides a segment of the dosage form that is of sufficient rigidity to withstand the contractions of the stomach and delay expulsion of the dosage form from the stomach until substantially all of the active agent has been dispensed.
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Dong Liang-Chang
Edgren David E.
Gardner Phyllis I.
Jao Francisco
Theeuwes Felix
ALZA Corporation
Dhuey John A.
Spear James M.
Stone Steven F.
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