Prolonged preservation of blood platelets

Details Prolonged preservation of blood platelets Prolonged preservation of blood platelets

1994-10-19

1997-04-22

Housel, James C.

Chemistry: analytical and immunological testing

Composition for standardization, calibration, simulation,...

Preservative, buffer, anticoagulant or diluent

436 63, 436176, 435 2, 424532, A61K 3514

Patent

active

056228678

ABSTRACT:
This invention provides a method for prolonging the preservation of human blood platelets at reduced temperatures. The method uses an inhibitor system that enables blood platelets to maintain their discoid shape and retain their functional integrity during storage. This is accomplished by interrupting normal platelet function during storage, so as to help keep platelets from activating and losing their shape. Before using the platelets in a transfusion, they are returned to their normal functional level by washing the inhibitor system away from the platelets.

REFERENCES:
patent: 4940581 (1990-07-01), Mason et al.
patent: 5256559 (1993-10-01), Maraganore et al.
Becker et al. "Effect of PGE1 on harvesting of plates from . . . " J. Lab. Clin. Med. (1974), abs 80:93687 CA.
Teng et al. "Platelet aggregation induced by equinatoxin" Thromb. Res. (1988) 52 (5) 401-11.
Teng et al "Triwaglerin: a potent platelet aggregation . . . " Biochim. Biophys. Acta (1989), 992(3), 258-64.
Narayanan "Inhibition of in vitro platelet aggregation . . . " Ann. Clin. Lab. Sci. (1989) 19(4), 260.5.
Two entries of the same abstract of Stephen Lindsey's "Confidential Proposal to Small Business Innovation Research (SBIR) Program" found in the Federal Research in Progress Data Base on Dialog. We do not know the publication date of these abstracts.
R. Valeri, H. Feingold, and L.D. Marchionni, A Simple Method for Freezing Human Platelets Using Dimethylsulfoxide and Storage at -80.degree.C, Blood, vol. 43, No. 1 (Jan.), 1974.
A.P. Bode, S. Holme, W.A. Heaton, and M.S. Swanson, Extended Storage of Platelets in an Artificial Medium with the Platelet Activation Inhibitors Prostaglandin E, and Theophylline, Vox Sang 1991:60;105-112.

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