Prolonged cold storage of red blood cells by oxygen removal and

Details Prolonged cold storage of red blood cells by oxygen removal and Prolonged cold storage of red blood cells by oxygen removal and

1997-05-15

1998-08-04

Achutamurthy, Ponnathapura

Chemistry: molecular biology and microbiology

Maintaining blood or sperm in a physiologically active state...

604 4, A01N 102, A61M 3700

Patent

active

057891516

ABSTRACT:
Prolonged cold storage of red blood cells by oxygen removal and additive usage. A cost-effective, 4.degree. C. storage procedure that preserves red cell quality and prolongs post-transfusion in vivo survival is described. The improved in vivo survival and the preservation of adenosine triphosphate levels, along with reduction in hemolysis and membrane vesicle production of red blood cells stored at 4.degree. C. for prolonged periods of time, is achieved by reducing the oxygen level therein at the time of storage; in particular, by flushing the cells with an inert gas, and storing them in an aqueous solution which includes adenine, dextrose, mannitol, citrate ion, and dihydrogen phosphate ion, but no sodium chloride, in an oxygen-permeable container which is located in an oxygen-free environment containing oxygen-scavenging materials.

REFERENCES:
patent: 4585735 (1986-04-01), Meryman et al.
patent: 5476764 (1995-12-01), Bitensky
patent: 5624794 (1997-04-01), Bitensky et al.

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