Prolonged-action immunotoxins containing a glycopeptide constitu

Details Prolonged-action immunotoxins containing a glycopeptide constitu Prolonged-action immunotoxins containing a glycopeptide constitu

1989-03-02

1993-02-09

Draper, Garnette D.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

5303915, 5303911, 5303919, 530402, 530403, 530404, 530405, 530406, 530395, 530396, 424 8591, C07K 1528, C07K 306

Patent

active

051854341

ABSTRACT:
Prolonged-action immunotoxin consisting of a conjugate in which an antibody or antibody fragment is coupled, by means of a covalent structure containing a disulfide group or a thioether group, with a glycoprotein which inactivates ribosomes and has a prolonged action obtained by the oxidation of its saccharide units which periodate ions.

REFERENCES:
patent: 4340535 (1982-07-01), Voisin et al.
patent: 4749566 (1988-06-01), Casellas et al.
Vitetta et al, Cancer Drug Delivery, 2(3) 1985, pp. 191-198 Collier, 190th ACS National Meeting Sep. 8-13, 1985 (abst only).

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