Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices
Reexamination Certificate
1994-09-30
2001-03-27
Webman, Edward J. (Department: 1502)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Matrices
C424S440000, C424S441000
Reexamination Certificate
active
06207192
ABSTRACT:
BACKGROUND OF THE INVENTION
Water soluble organic compounds, such as comestibles and therapeutic agents, are incorporated into syrups or hard candy, as a means of prolonging the activities of active ingredients, such as menthol in breath fresheners, or therapeutic agents.
A simple hard candy throat lozenge is a known means of supplying a therapeutic agent to the oral cavity and esophagus of a warm blooded host. See MUCIN, U.S. Pat. No. 4,921,644.
However, the same simple means is not readily available for prolonging the active time frame for the organic therapeutic compounds, such as p-aminobenzoic acid ethylester. The organic substance cannot be readily incorporated in candy for extended application, because, when the candy is gone, so is the flavorant, such as menthol. Elixir liquid, to be effective, must be limited to fast action, which in turn, effects the treatment time.
OBJECTS OF THE INVENTION
It is an object of the invention to prolong the retention of flavorant taste or soothing action pharmaceuticals, in the oral cavity of a warm-blooded host.
Another object of the invention is to employ a dispenser to extend the time of application of comestibles and therapeutic substances to the oral cavity, esophagus, eye, vagina, bladder, rectal cavity, stomach, and all mucin coated surfaces in the warm-blooded host.
Another object of the invention is to incorporate an organic active substance in a carrier, said carrier having an affinity for mucin and thereby holds the carrier in a desired location to release active substance over a time span.
The reference with respect to affinity to mucin is a statement of a means to anchor the active ingredients in a favorable location, and has no reference to the time extension which is the object of the invention.
SUMMARY
The preferred embodiment of this invention utilizes amphiphilic substances to adhere to mucin surfaces and provides a hydrophobic reservoir which can entrap and sequester organic compounds, comestibles, and therapeutic agents in order to prolong their effect in a warm-blooded host.
DEFINITION
Cetyl pyridinium chloride hereafter will be represented by the acronym: CPC.
Critical micelle concentration will be represented by the acronym: CMC.
REFERENCES:
patent: 5236699 (1993-08-01), Libin
Fay Sharpe Beall Fagan Minnich & McKee
SDG, Inc.
Webman Edward J.
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