Proline-, glycine- and lysine-based pharmaceutical...

Details Proline-, glycine- and lysine-based pharmaceutical... Proline-, glycine- and lysine-based pharmaceutical...

1999-12-13

2001-08-07

Rose, Shep K. (Department: 1614)

Drug, bio-affecting and body treating compositions

Dentifrices

Ammonia, amine, or derivative thereof

C424S200100

Reexamination Certificate

active

06270750

ABSTRACT:

SUMMARY
The present invention regards the preparation of pharmaceutical compositions substantially based on proline, glycine and lysine, capable of promoting proliferation of fibroblasts with production of collagen, in the treatment of periodontal diseases, both in the form of injectable solution and in the form of a mouth-wash, toothpaste, or gengival gel.
PRIOR ART
The U.S. Pat. No. 5,198,465 describes a proline-, glycine- and lysine-based composition, possibly also comprising methionine, cysteine, Vitamin C and other ingredients, the said composition being capable of inducing or promoting the biological synthesis of collagen in the situations in which this synthesis is deficient. According to this document of the prior art, the above composition, in which the essential amino acids, i.e., proline, glycine and lysine, are present in specific weight ratios to one another, can be formulated with diluents and excipients of an oily type or not, in a form suitable for external topical use, or else it is formulated suitably for oral administration.


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patent: 5717909A (1982-10-01), None
patent: WO9627371 (1996-12-01), None
patent: 9826774A1 (1998-06-01), None

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