Proline derivatives possessing prolyl endopeptidase-inhibitory a

Details Proline derivatives possessing prolyl endopeptidase-inhibitory a Proline derivatives possessing prolyl endopeptidase-inhibitory a

1993-02-26

1996-04-09

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548518, 548524, A61K 3140, C07D40306, C07D40314

Patent

active

055062563

ABSTRACT:
Novel proline derivatives of the following formula (I) ##STR1## wherein each symbol is as defined in the specification, which specifically inhibit prolyl endopeptidase activity and can be used for the prevention and/or treatment of dementia and amnesia as agents which act directly on the central symptoms of dementia.

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patent: 4857537 (1989-08-01), Toda et al.
patent: 4880827 (1989-11-01), Tamoto et al.
patent: 4912128 (1990-03-01), Henning et al.
Patent Abstracts of Japan, vol. 11, No. 332, (C-455)(2779) Oct. 29, 1987, Abstract of Japan 62-114957(A).
Patent Abstracts of Japan, vol. 13, No. 273, (C-609)(3621) Jun. 22, 1989, Abstract of Japan 62-225377.
Patent Abstracts of Japan, vol. 11, NO. 332, (C-455)(2779) Oct. 29, 1987, Abstract of Japan 62-114978.

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