Proline derivatives

Details Proline derivatives Proline derivatives

1990-02-08

1992-10-27

Brust, Joseph P.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548518, 548539, 548540, A61K 3140, C07D40306

Patent

active

051589702

ABSTRACT:
New proline derivatives of the general formula: ##STR1## wherein R stands for a lower alkyl group and X for a N-terminal protective group conventional in amino acid chemistry or an acyl group derived from an amino acid with a protective group at the N-terminal. They have inhibitory activity against prolylendopeptidase and are relatively chemically stable as compared with known compounds of this type.

REFERENCES:
patent: 4687778 (1987-08-01), Tsuru et al.
patent: 4701465 (1987-10-01), Tanaka et al.
patent: 4743616 (1988-05-01), Tanaka et al.
patent: 4772587 (1988-09-01), Tanaka et al.
patent: 4873342 (1989-10-01), Tanaka et al.
patent: 4880827 (1989-11-01), Tamoto et al.
patent: 4929633 (1990-05-01), Shibahara et al.
patent: 5051444 (1991-09-01), Tamoto et al.
Tetrahedron Letters, vol. 27, No. 5, Dec. 1986 pp. 6111-6114, Mori et al.

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