Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-04-10
2007-04-10
Kifle, Bruck (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S411000, C540S456000, C540S457000
Reexamination Certificate
active
11103779
ABSTRACT:
Methods for the synthesis of CCI-779 and proline-CCI-779 are described, including a method involving lipase-catalyzed acetylation of 42-hydroxy of rapamycin with a vinyl ester of 2,2-bis(hydroxymethyl) propionic acid in an organic solvent followed by deprotection. Also provided are products containing proline-CCI-779 and uses thereof.
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Chew Warren
Gu Jianxin
Raveendranath Panolil
Ruppen Mark E.
Shaw Chia-Cheng
Howson & Howson LLP
Kifle Bruck
Milowsky Arnold S.
Wyeth
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