Proliferated cell lines and uses thereof

Details Proliferated cell lines and uses thereof Proliferated cell lines and uses thereof

2003-02-07

2008-08-26

Yaen, Christopher H. (Department: 1643)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Reexamination Certificate

active

07416885

ABSTRACT:
The subject invention pertains to tumor cell lines useful for increasing the proliferation potential of any human or animal cell in culture, thereby providing immortalized or continuous cell lines and cultures. The invention also concerns proliferation factors, and compositions containing the factors, which are capable of increasing the proliferation potential of any human or other animal cell in culture. The subject invention further pertains to a method for proliferation cells in culture by contacting cells with the proliferation factors. The proliferated cells can range in plasticity and can include, for example, blast cells, fertilized ova, non-fertilized gametes, embryonic stem cells, adult stem cells, precursor or progenitor cells, and highly specialized cells. Optionally, the cells can be induced to cease proliferation. The proliferation cells of the subject invention are useful for cell therapy, cell/gene therapy, biological production of molecules, and as in vitro models for research, toxicity testing, and drug development.

REFERENCES:
Hartung T. et al. ATLA 30: 407-414, 2002.
Allen, D.D. et al. “Impaired cholinergic function in cell lines derived from the cerebral cortex of normal and trisomy 16 mice”Eur. J. Neuroscience, 2000, 12:3259-3264.
Arriagada, C. et al. “Cells of the Neuronal Cell Line CTB, Derived from the Cerebral Cortex of a Trisomy 16 Mouse, Accumulate Amyloid in Intracytoplasmic Vacuole-Like Compartments” Society for Neuroscience Meeting Abstract, Sunday, Nov. 5, 2000.
Arriagada, C. et al. “Studies of aminochrome toxicity in a mouse derived neuronal cell line: is this toxicity mediated via glutamate transmission?”Amino Acids, 2000, 18:363-373.
Cardenas, A.M. et al. “Immortalized Neuronal Cell Lines From the Spinal Cord of Normal and Trisomy 16 Fetal Mice, an Animal Model of Down Syndrome” Society for Neuroscience Meeting Abstract, Wednesday, Nov. 14, 2001.
Cardenas, A.M. et al. “Calcium signals in cell lines derived from the cerebral cortex of normal and trisomy 16 mice”NeuroReport, 1999, 10:363-369.
Caviedes, P. et al. “Calcium Fluxes, Ion Currents and Dihydropyridine Receptors in a New Immortal Cell Line from Rat Heart Muscle”Mol. Cell. Cardiol., 1993, 25:829-845.
Caviedes, P. et al. “The role of altered sodium currents in action potential abnormalities of cultured dorsal root ganglion neurons from trisomy 21 (Down syndrome) human fetuses”Brain Res., 1990, 510:229-236.
Caviedes, R. et al. “Ion Channels in a Skeletal Muscle Cell Line from a Duchenne Muscular Dystrophy Patient”Muscle&Nerve, 1994, 17:1021-1028.
Caviedes, R. et al. “A human skeletal muscle cell line obtained from an adult donor”Biochimica et Biophysica Acta, 1992, 1134:247-255.
Caviedes, R. et al. “Tetrodotoxin-Sensitive Sodium Channels in a Continuously Cultured Cell Line Derived from the Adult Rat Cerebellum”Brain Res., 1986, 365:259-268.
Caviedes, R. and J.B. Stanbury “Studies on a Cell Line from a Functional Rat Thyroid Tumor in Continuous Culture”Endocrinology, 1976, 99:549-554.
Freeman, T.B. et al. “Neural Transplantation in Parkinson's Disease”Parkinson's Disease: Advances in Neurology, Chapter 46, 2001, 86:435-445.
Freeman, T.B. et al. “Transplanted fetal striatum in Huntington's disease: Phenotypic development and lack of pathology”PNAS, Dec. 5, 2000, 97(25):13877-13882.
Freeman, T.B. et al. “Neural transplantation for the treatment of Huntington's disease”Progress in Brain Res., Chapter 18, 2000, 127:405-411.
Freeman, T.B. et al. “Bilateral Fetal Nigral Transplantation into the Postcommissural Putamen in Parkinson's Disease”Annuals of Neurology, Sep. 1995, 38(3):379-388.
Freeman, T.B. et al. “Cross-species intracerebral grafting of embryonic swine dopaminergic neurons”Progress in Brain Res., Chapter 61, 1988, 78:473-477.
Hernandez, R.A. et al. “MPP+ but not MPTP Induces Toxicity and Apoptosis in the Neuronal Dopaminergic Cell Line RCSN-3” Society for Neuroscience Meeting Abstract, Tuesday, Nov. 5, 2002.
Kin, T. et al. “Development of an Immunoprivileged Site to Prolong Islet Allograft Survival”Cell Transplantation, 2002, 11:547-552.
Liberona, J.L. et al. “Differences in Both Inositol 1,4,5-Trisphosphate Mass and Inositol 1,4,5-Trisphosphate Receptors Between Normal and Dystrophic Skeletal Muscle Cell Lines”Muscle Nerve, 1998, 21:902-909.
Lima, A.C.P. et al. “Nitrophenols Reduce the content of Intracellular β Amyloid in the CTB Neuronal Cell Line, Derived from the Trisomy 16 Mouse” Society for Neuroscience Meeting Abstract, Tuesday, Nov. 5, 2002.
Martin, G.R. “Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells”Proc. Natl. Acad. Sci., Dec. 1981, 78(12):7634-7638.
Sanberg, P.R. et al. “Transplantation of Testis-Derived Sertoli Cells into the Mammalian Brain”Transplantation Proceedings, 1997, 29:1926-1928.
Segura-Aguilar, J. et al. “The Dopamine Oxidation Product Aminochrome Induces Apoptosis in the RCSN-3 Dopaminergic Cell Line” Society for Neuroscience Meeting Abstract, Tuesday, Nov. 5, 2002.
Segura-Aguilar, J.E. et al. “The Role of DT-Diaphorase in Dopaminergic Neurons” Society for Neuroscience Meeting Abstract, Monday, Nov. 12, 2001.
Tsai, R. and R. McKay “A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells”Genes&Development, 2002, 16:2991-3003.
Willing, A.E. et al. “Sertoli cells decrease microglial response and increase engraftment of human hNT neurons in the hemiparkinsonian rat striatum”Brain Res. Bulletin, 1999, 48(4):441-444.
Willing, A.E. et al. “Sertoli cells enhance the survival of co-transplanted dopamine neurons”Brain Res., 1999, 822:246-250.
Hurtado-Guzman, C. et al. “J. Neurotoxicity of MAO inhibitors in adult rat hypothalamic cell culture”Neurotoxicity Res., 2002, 4(2):161-163.
Cardenas, A.M. et al. “Cell lines derived from hippocampal neurons of the normal and trisomy 16 mouse fetus (a model for Down syndrome) exhibit neuronal markers, cholinergic function, and functional neurotransmitter receptors”Exp. Neurol., Sep. 17, 2002, 177(1):159-170.
Paris, I. et al. “Copper neurotoxicity is dependent on dopamine-mediated copper uptake and one-electron reduction of aminochrome in a rat substantia nigra neuronal cell line”J. Neurochemistry, 2001, 77:519-529.
Dagnino-Subiabre, A. et al. “Angiotensin receptor II is present in dopaminergic cell line of rat substantia nigra and it is down regulated by aminochrome”Mol. Cell. Biochemistry, 2000, 212:131-134.
Amar, A.P. et al. “Endovascular Restorative Neurosurgery: A Novel Concept for Molecular and Cellular Therapy of the Nervous System”Neurosurgery, 2003, 52(2):402-413.
Bergers, G. and D. Hanahan “Cell factories for fighting cancer”Nature Biotechnology, Jan. 2001, 19:20-21.
Couzin, J. “Select T Cells, Given Space, Shrink Tumors”Science, Sep. 20, 2002, 297:1973.
Dove, A. “Cell-based therapies go live”Nature Biotechnology, Apr. 2002, 20:339-343.
Dudley, M.E. et al. “Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes”Science, Oct. 25, 2002, 298:850-854.
Freed, W.J. “Functional Brain Tissue Transplantation: Reversal of Lesion-Induced Rotation by Intraventricular Substantia Nigra and Adrenal Medulla Grafts, with a Note on Intracranial Retinal Grafts”Biological Psychiatry, 1983, 18(11):1204-1267.
Griffith, L.G. and G. Naughton “Tissue Engineering—Current Challenges and Expanding Opportunities”Science, Feb. 8, 2002, 295:1009-1014.
Halvorsen, T. et al. “In Vivo Glucose-Responsive Insulin Secretion from a Human Pancreatic β-Cell

Affiliated with

Also associated with

Rating

Proliferated cell lines and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Proliferated cell lines and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Proliferated cell lines and uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4006826