Coating processes – Medical or dental purpose product; parts; subcombinations;... – Particulate or unit-dosage-article base
Patent
1995-04-13
1997-03-11
Lovering, Richard D.
Coating processes
Medical or dental purpose product; parts; subcombinations;...
Particulate or unit-dosage-article base
424452, 427 215, 4272133, 426 96, 426453, 514962, 514974, A61K 916, A23L 1305
Patent
active
056099096
ABSTRACT:
Prolamine fractions of grain proteins, applied as a single coating in weight ratios of 5 to 100% relative to the active substance being coated, result in the production of a liquid suspension which effectively masks the taste of orally administered drugs which often are extremely bitter. The taste masking is stable over prolonged periods of storage time of the suspension. The prolamine coating does not restrict the immediate bioavailability of the active substance. Prolamine coating is effective in masking the taste of antibiotics, vitamins, dietary fiber, analgesics, enzymes and hormones. Zein, gliadin or a mixture thereof, particularly in combination with between 2.5 and 15% of a water insoluble vegetable source oil or a wax capable of plasticizing the prolamine fraction, when applied to particles of drugs or nutritional supplements, to an effective thickness of about 1 to about 35 micrometers, are particularly effective in preventing the release of the active substance from the encapsulated particle and also in masking the unpleasant taste of the coated active substance.
REFERENCES:
patent: 3351531 (1967-11-01), Noznick et al.
patent: 3365365 (1968-01-01), Butler et al.
patent: 3497369 (1970-02-01), Martin
patent: 3786123 (1974-01-01), Katzen
patent: 3802896 (1974-04-01), Westal l et al.
patent: 3922379 (1975-11-01), Farhadieh
patent: 3939259 (1976-02-01), Pescetti
patent: 4079131 (1978-03-01), Lin et al.
patent: 4137300 (1979-01-01), Sheth et al.
patent: 4332790 (1982-06-01), Sozzi et al.
patent: 4384004 (1983-05-01), Cea et al.
patent: 4418084 (1983-11-01), Murray et al.
patent: 4433076 (1984-02-01), Bauer et al.
patent: 4661359 (1987-04-01), Seaborne et al.
patent: 4749575 (1988-06-01), Rotman
patent: 4800087 (1989-06-01), Mehta
patent: 4876094 (1989-10-01), Benton et al.
patent: 4876097 (1989-10-01), Autant et al.
patent: 4931295 (1990-06-01), Courtright et al.
patent: 5008117 (1991-04-01), Calanchi et al.
patent: 5049394 (1991-09-01), Howard et al.
patent: 5077053 (1991-12-01), Kuncewitch et al.
patent: 5085868 (1992-02-01), Mattsson et al.
patent: 5098718 (1992-03-01), Ardaillon et al.
patent: 5108757 (1992-04-01), Erdos et al.
patent: 5271961 (1993-12-01), Mathiowitz et al.
Gennadios et al., Food Technology, Oct. 1990, pp. 63-69.
Mazer Terrence B.
Meyer Glenn A.
Abbott Laboratories
Brainard T. D.
Drayer L. R.
Lovering Richard D.
Nickey D. O.
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