Prolactin as a vaccine adjuvant

Details Prolactin as a vaccine adjuvant Prolactin as a vaccine adjuvant

1994-02-14

1996-12-17

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

4241921, 514 12, 530399, A61K 3700, A61K 3818, A61K 3822

Patent

active

055850995

ABSTRACT:
The present invention relates to a composition for enhancing the immune response of an animal to an infectious disease vaccine wherein the composition comprises prolactin. Preferably, the composition is human prolactin and the animal to be vaccinated is, as well, human.
The present invention further relates to a composition for enhancing the immune response of an animal to an infectious disease vaccine wherein the composition comprises prolactin cDNA. Human prolactin cDNA is preferred.

REFERENCES:
patent: 4725549 (1988-02-01), Cooke et al.
patent: 5028591 (1991-07-01), Edwards et al.
Nagy, E. and Berczi I. (1978) "Immunodeficiency in Hypophysectomized Rats" ACTA Endocrin, vol. 89:530-537.
Spangelo, B. et al. (1987) "Stimulation of in-vivo antibody Production and Concanavalin-A-induced Mouse Spleen Cell Mitogenesis by Prolactin" Immunopharm., vol. 14:11-20.
Felgner P. et al. (1987) "Lipofection: A Highly Efficient Lipid-mediated DNA-transfection Procedure" Proc. Natl. Acad. Sci. USA, 84(11):7413-7417.
Bernton, E. et al. (1988) "Suppression of Macrophage Activation and T-Lymphocyte Function in Hypoprolactinemic Mice" Science, 239(1/22): 401-404.
Mukherjee, P. et al. (1990) "Prolactin Induction of Interleukin-2 Receptors on Rat Splenic Lymphocytes" Endocrin., 126(1): 88-94.
Clevenger, C. et al. (1990) "Regulation of Interleukin 2-driven T-lymphocyte Proliferation by Prolactin" Proc. Nat. Acad. Sci. USA 87(8): 6460-6464.
Stephenson, J. et al. (1991) "Adjuvant Effect of Human Growth Hormone with an Inactivated Flavivirus Vaccine" J. Infec. Dis., 164: 188-191.
Pellegrini, I. et al. (1992) "Expression of Prolactin and its Receptor in Human Lymphoid Cells" Mol. Endo., 6(7): 1023-1031.
Ulmer, J. et al. (1993) "Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein" Science, 259(3/19): 1745-1749.
Murphy, W. et al. (1993) "Differential Effects of Growth Hormone and Prolactin on Murine T Cell Development and Function" J. Exp. Med., 178(7): 231-236.

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