Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing
Reexamination Certificate
2006-05-30
2006-05-30
Andres, Janet L. (Department: 1646)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
C435S004000, C435S007210, C435S183000
Reexamination Certificate
active
07052674
ABSTRACT:
The invention provides isolated polypeptides that stimulate gastrointestinal smooth muscle contraction, including human prokineticin 1 and human prokineticin 2 polypeptides, and functional fragments and modifications thereof. Also provided are methods of stimulating gastrointestinal smooth muscle contraction in a mammal, by administering to the mammal an effective amount of a prokineticin polypeptide. The invention also provides nucleic acid molecules encoding a prokineticin polypeptide, and antibodies that selectively bind a prokineticin polypeptide. Further provided are methods of identifying a prokineticin receptor ligand, agonist or antagonist.
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Ehlert Frederick J.
Zhou Qun-Yong
Andres Janet L.
DLA Piper Rudnick Gray Cary US LLP
The Regents of the University of California
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