Prokineticin 2β peptide and its use

Details Prokineticin 2β peptide and its use Prokineticin 2β peptide and its use

2005-03-29

2009-11-03

Weber, Jon P (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

C530S350000, C514S002600, C514S012200

Reexamination Certificate

active

07612163

ABSTRACT:
A PK2β peptide is described, which, as an agonist of prokineticin receptor 1, is useful for treating lung and gastrointestinal diseases or disorders mediated by PKR1 activity.

REFERENCES:
patent: 2003/0059856 (2003-03-01), Ames et al.
patent: 2003/0092623 (2003-05-01), Ferrara et al.
patent: 2003/0235535 (2003-12-01), Zhou et al.
Achem et al., “A prokinetic approach to treatment of gastroesophageal reflux disease”,Dig Dis., 1998, 16:38-46.
Arad et al., “The fetal inflammatory response syndrome and associated infant morbidity”,IMAJ, 2004, 6:766-769.
Briejer et al, “Idiopathic constipation: too few stools and too little knowledge”,Trends Pharmacol. Sci., 1999, 20:1-3.
Bullock et al., “Structural determinants required for the bioactivities of prokineticins and identification of prokinectin receptor antagonists”,Mol Pharmacology, 2004, 65(3):582-588.
Chabre et al., “Coupling of the alpha 2A-adrenergic receptor to multiple G-proteins. A simple approach for estimating receptor-G-protein coupling efficiency in a transient expression system”,J Biol Chem., 1994, 269(8):5730-5734.
Cheng et al., “Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus”,Nature, 2002, 417:405-410.
Conklin et al., “Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha”,Nature, 1993, 363:274-276.
Efthimiou et al, “Role of biological agents in immune-mediated inflammatory diseases”,South Med J., 2005, 98(2): 192-204.
Ferrara et al., “Differential expression of the angiogenic factor genes vascular endothelial growth factor (VEGF) and endocrine gland-derived VEGF in normal and polycystic human ovaries”,Am. J. Pathol., 2003,162(6):1881-1893.
Hachem et al., “Bronchiolitis obliterans syndrome: pathogenesis and management”,Semin Thorac Cardiovasc Surg., 2004, 16(4):350-355.
Hickey et al., “Clinical implications of disturbances of uterine vascular morphology and function”,Baillieres Clin Obstet Gynaecol., 2000, 14(6):937-951.
Kisliouk et al., “Presence and regulation of endocrine gland vascular endothelial growth factor/prokineticin-1 and its receptors in ovarian cells”,J Clin Endocrinol Metab., 2003, 88(8):3700-3707.
LeCouter et al., “Identification of an angiogenic mitogen selective for endocrine gland endothelium”,Nature, 2001, 412:877-884.
LeCouter et al., “Endocrine gland-derived VEGF and the emerging hypothesis of organ-specific regulation of angiogenesis”,Nat Med., 2002, 8(9):913-917.
LeCouter et al., “The role of EG-VEGF in the regulation of angiogenesis in endocrine glands”,Cold Spring Harb Symp Quant Biol., 2002, 67:217-221.
LeCouter et al., “The endocrine-gland-derived VEGF homologue Bv8 promotes angiogenesis in the testis: Localization of Bv8 receptors to endothelial cells”,Proc Natl Acad Sci USA, 2003, 100(5):2685-2690.
LeCouter et al., “Mouse endocrine gland-derived vascular endothelial growth factor: a distinct expression pattern from its human ortholog suggests different roles as a regulator of organ-specific angiogenesis”,Endocrinology, 2003, 144(6):2606-2616.
Li et al., “Identification of two prokineticin cDNAs: Recombinant proteins potently contract gastrointestinal smooth muscle”,Mol Pharmacol, 2001, 59(4):692-698.
Lin et al., “Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor”,J Biol Chem., 2002, 277(22):19276-19280.
Lin et al., “Characterization of endocrine gland-derived vascular endothelial growth factor signaling in adrenal cortex capillary endothelial cells”,J Biol Chem., 2002, 277(10):8724-8729.
Liu et al., “Cloning and pharmacological characterizaiton of a fourth histamine receptor (H4) expressed in bone marrow”,Mol Pharmacol., 2001, 59(3):420-426.
Liu et al., “Comparison of human, mouse, rat and guinea pig histamine H4 receptors reveals substantial pharmacological species variation”,J Pharmacol Exp Ther., 2001, 299(1):121-130.
Liu et al., “Involvement of both Gq/11 and Gs proteins in gonadotropin-releasing hormone receptor-mediated signaling in LβT2 cells”,J Biol Chem., 2002, 277(35):32099-32108.
Masuda et al., “Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors”,Biochem Biophys Res Commun., 2002, 293:396-402.
Medford et al., “Vascular endothelial growth factor gene polymorphism and acute respiratory distress syndrome”,Thorax, 2005, 60:244-248.
Mollay et al. “Bv8, a small protein from frog skin and its homologue from snake venom induce hyperalgesia in rats”,Eur J Pharmacol., 1999, 374:189-196.
Nakayama, “Furin: a mammalian subtilisin/kex2p-like endoprotease involved in processing of a wide variety of precursor proteins”,Biochem J., 1997, 327:625-635.
Negri et al., “Nociceptive sensitization by the secretory protein Bv8,”Br J Pharmacol., 2002, 137(8):1147-1154.
Samsom et al., “Abnormal gastric and small intestinal motor function in diabetes mellitus”,Dig Dis., 1997, 15:263-274.
Schweitz et al., “Purification and pharmacological characterization of peptide toxins from the black mamba (Dendroaspis polylepis) venom”,Toxicon, 1990, 28(7):847-856.
Schweitz et al., “MIT(1), a black mamba toxin with a new and highly potent activity on intestinal contraction”,FEBS Lett., 1999, 461:183-188.
Soga et al., “Molecular cloning and characterization of prokineticin receptors,”Biochim. Biophys. Acta., 2002, 1579:173-179.
Steiner et al., “The new enzymology of precursor processing endoproteases”,J Biol Chem., 1992, 267(33):23435-23438.
Tonini, “Recent advances in the pharmacology of gastrointestinal prokinetics”,Pharmacol Res., 1996, 33(4-5):217-226.
Wechselberger et al., “The mammalian homologues of frog Bv8 are mainly expressed in spermatocytes”,FEBS Lett., 1999, 462:177-181.
Weissgerber et al., “The role of regular physical activity in preeclampsia prevention”,Med. Sci. Sports Exerc., 2004, 2024-2031.
Yanagita et al., “Processing of mutated proinsulin with tetrabasic cleavage sites to mature insulin reflects the expression of furin in nonendocrine cell lines”,Endocrinology, 1993, 133(2): 639-644.
Zhang et al., “Expression of endocrine gland-derived vascular endothelial growth factor in ovarian carcinoma”,Clin Cancer Res., 2003, 9:264-272.

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