Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Reexamination Certificate
2004-08-02
2011-10-11
Hutson, Richard (Department: 1652)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
C435S183000, C435S194000, C435S091400, C435S091510, C435S091520
Reexamination Certificate
active
08034587
ABSTRACT:
The present invention relates to the cloning and characterization of a prokaryotic DNA repair ligase, which is shown to possess a range of activities that allow the ligation and repair of non-compatible DNA ends and double strand breaks (DSBs). The enzyme has a range of applications in the manipulation and cloning of nucleic acids.
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Srivastava et al., Journal of Biological Chemistry, vol. 280, No. 34, pp. 30273-30281, 2005.
Cole et al., Uniprot Accession No. P71571, May 30, 2000.
Aravind et al., “Prokaryotic homologs of the eukaryotic DNA-end-binding protein Ku, novel domains in the Ku protein and prediction of a porkayrotic double-strand break repair system,” 11:1365-1374 (2001), Genome Research.
Doherty et al., “Identification of bacterial homologues of the Ku DNA repair proteins,” FEBS Letters, 500:186-188 (2001).
Weller et al., “A family of DNA repair ligares in bacteria?” FEBS Letters, 505:340-342, 2001.
Weller et al., “Identification of a DNA nonhomologous end-jointing complex in bacteria,”Science, 297:1686-1689 (2002).
Della Marina
Doherty Aidan
Jackson Stephen
Weller Geoffrey
Cambridge Enterprise Limited
Hutson Richard
Klarquist & Sparkman, LLP
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