Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Scleroproteins – e.g. – fibroin – elastin – silk – etc.
Reexamination Certificate
2007-07-03
2007-07-03
Weber, Jon (Department: 1656)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Scleroproteins, e.g., fibroin, elastin, silk, etc.
C530S350000
Reexamination Certificate
active
11245689
ABSTRACT:
The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host cells containing the expression vectors to produce these recombinant proteins and methods of production for the same. Additionally, antibodies are provided that are directed against a recombinant collagen-like protein that, preferably, binds an integrin. Furthermore, a method of screening for potential therapeutic compounds that inhibit the integrin-binding or -interacting activities of recombinant collagen-like proteins.
REFERENCES:
Rasmussen et al. SclA, a Novel Collagen-Like Surface Protein ofStreptococcus pyogenes. Infection and Immunity. Nov. 2000. vol. 68, No. 11, pp. 6370-6377.
Bowie et al. Deciphering the Message in the Protein Sequences: Tolerance to Amino Acid Substitutions. Science. 1990. vol. 247, pp. 13061013.
Wells J.A. Addidtivity of Mutational Effects in Proteins. Biochemistry. 1990. vol. 29, No. 37, pp. 8509-8517.
Sequence alignment of sequence from Rasmussen et al. with SEQ ID Nos. 16-25.
Höök Magnus
Lukomski Slawomir
Xu Yi
Adler Benjamin Aaron
Noakes Suzanne M.
The Texas A&M University System
Weber Jon
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