Progressive elevated gene-3 (PEG-3) induces aggressive...

Details Progressive elevated gene-3 (PEG-3) induces aggressive... Progressive elevated gene-3 (PEG-3) induces aggressive...

2006-01-03

2006-01-03

Keitter, James (Department: 1636)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S029000, C435S032000

Reexamination Certificate

active

06982148

ABSTRACT:
The present invention provides a method for identifying a gene which is expressed at a modulated level in an aggressive cancer by: (a) measuring baseline expression levels of genes in cancer cells; (b) introducing into the cancer cells an expression vector which directs expression of rat PEG-3; (c) measuring the expression levels of genes in the cells from step (b); and (d) identifying genes, the expression of which is modulated in an aggressive cancer. In another aspect of this invention, the measurement of expression levels of genes in step (a) and/or step (c) comprises measuring mRNA levels. In yet another aspect of the invention, the measurement of expression levels of genes in step (a) and/or step (c) comprises measuring RNA levels. In another aspect of the invention, the genes identified in step (d) are used for diagnosing whether a subject suffers from an aggressive form of cancer.

REFERENCES:
patent: 6146877 (2000-11-01), Fisher
patent: WO 9937776 (1999-07-01), None
patent: WO 9949898 (1999-10-01), None
Su et al. PEG-3, a nontransforming cancer progression gene, is a positive regulator of cancer aggresiveness and angiogenesis PNAS vol. 96 No. 26 pp15115-15120 Dec. 21, 1999.
Su et al., 1999, “PEG-3, a nontransforming cancer progression gene, is a positive regulator of cancer aggresiveness and angiogenesis”, PNAS 96:15115-15120.

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