Programmed release tablets containing naproxen

Details Programmed release tablets containing naproxen Programmed release tablets containing naproxen

1993-09-01

1996-01-02

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424489, 424468, 424470, A61K 920

Patent

active

054806500

ABSTRACT:
Programmed release tablets, to be administered by oral route, containing from 500 to 1,200 mg of naproxen, made by mixtures of an immediate release granulate dry compacted containing from 5% to 28% of naproxen, of a controlled release granulate dry compacted containing from 72% to 95% of naproxen and of a disintegrating agent. A portion of naproxen is released in a short time, so that the drug can quickly develop its therapeutic action reaching the necessary hematic levels, while the remaining portion is released in a longer interval of time, so as to allow the therapeutic coverage until the subsequent administration. The therapeutic coverage is effective for a period of 24 hours; thus the tablets object of the present invention are suitable for a once a day administration.

REFERENCES:
patent: 4888178 (1989-12-01), Rotini et al.
patent: 5204116 (1993-04-01), Edgren et al.
patent: 5232705 (1993-08-01), Wong et al.

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