Progesterone receptor ligands

Details Progesterone receptor ligands Progesterone receptor ligands

1985-09-30

1988-10-25

Warden, Robert J.

Chemistry: analytical and immunological testing

Biospecific ligand binding assay

Utilizing isolate of tissue or organ as binding agent

436501, 436504, 436815, 436817, 260397, 2603974, 2603975, 514169, 514178, G01N 33566, G01N 33567, C07J 100, C07J 300

Patent

active

047804203

ABSTRACT:
Radiodinated and non-radiodinated 16.alpha.-iodo- and 17.alpha.-(2-iodovinyl)-19-nortestosterones are prepared and are used in progesterone receptor assays.

REFERENCES:
patent: 3498975 (1970-03-01), Oberster et al.
patent: 4321208 (1982-03-01), Sahadevan
patent: 4465676 (1984-08-01), Hochberg
patent: 4541957 (1985-09-01), Nakatsuka et al.
Pichon, M. F., et al., Cancer Research 37: 464-471, (1977).
Hanson, R. N., et al., Journ. Nucl. Med., 23: 431-436, (1982).
"Receptor-Binding Radiotracers: A Class of Potential Radiopharmaceuticals", by William C. Eckelman et al., J. Nucl. Med. 20, 350-357 (1979).
"Radiochemistry and Radiopharmaceuticals" , by Mazaitis, J. K., et al., J. Nucl. Med. 21, 142-146 (1980).
"Iodohexestrols. II. Characterization of the Binding and Estrogenic Activity of Iodinated Hexestrol Derivatives, in Vitro and in Vivo", by Katzenellenbogen, J. A., et al., Biochemistry 14, 1742-1750 (1975).
"Iodoestrogens, Syntheses, and Interaction with Uterine Receptors" , by Arunachalam, T., et al., J. Biol. Chem. 254, 5900-5905 (1979).
"Iodine-125-Labeled Estradiol: A Gamma-Emitting Analog of Estradiol That Binds to the Estrogen Receptor" , by Hochberg, R. Science 205, 1138-1140 (1979).
"Synthesis of 16.alpha.-[.sup.125 I] Iodo-5 -Dihydroteststerone . . . ", by Hoyte, R. M., J. Steroid Biochem. 16, 621-628 (1982).
"17.beta.-Carboxamide Steroids are a New Class of Glucocorticoid Antagonists", by Rousseau, G. G., et al., Nature 279, 158-160 (1979).
"Synthesis and Evaluation of Potential Radioligands for the Progesterone Receptor", by Hoyte, R. M. et al., J. Med. Chem. 28, 1695-1699 (1985).

Affiliated with

Also associated with

Rating

Progesterone receptor ligands does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Progesterone receptor ligands, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Progesterone receptor ligands will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2269384