Chemistry: molecular biology and microbiology – Vector – per se
Patent
1992-05-14
1994-11-15
Hill, Jr., Robert J.
Chemistry: molecular biology and microbiology
Vector, per se
536 231, 435 78, 530350, C12N 1500, C07H 1700, G01N 3353, C07K 1300
Patent
active
053647912
ABSTRACT:
The present invention provides mutant proteins of steroid hormone receptors. These mutant proteins are useful in methods of distinguishing a steroid hormone receptor antagonist from a steroid hormone receptor agonist. The present invention also provides plasmids containing mutated steroid hormone receptor proteins and cells transfected with those plasmids. In addition, the present invention provides methods for determining whether a compound is a steroid hormone receptor antagonist or agonist. Also, the present invention provides methods of determining endogenous ligands for steroid hormone receptors.
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McDonnell Donald P.
O'Malley Bert W.
Vegeto Elisabetta
Carlson K. Cochrane
Hill Jr. Robert J.
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