Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1996-11-04
1999-11-16
Cook, Rebecca
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
514177, 424433, 424 7016, A61K 3156
Patent
active
059858613
ABSTRACT:
The present invention provides a method of treating or reducing ischemia or incidence of cardiovascular events by administering progesterone. Progesterone, unlike synthetic progestins, has been demonstrated to supplement, rather than to decrease, the beneficial effects of estrogen therapy on myocardial ischemia in females.
REFERENCES:
patent: 5543150 (1996-08-01), Bologna et al.
Giuseppe Rosano, et al., Medroxyprogesterone but not natural progesterone reverses the beneficial effect of estradiol 17 beta upon exercise-induced myocardial ischemia, Circulation (Supplement), vol. 94, No. 8. p. 18 (Oct. 15, 1996).
Rosano, G.M.C. et al., "Medroxyprogesterone acetate (MPA) but not natural progesterone (P) reverse the effect of estradiol 17 beta (E2) upon exercise induced myocardial ischemia. A double-blind cross-over study," Maturitas 27 (Suppl.), 8th Intern. Cong. on the Menopause, Australia (Nov. 1996).
Jiang C., et al., "Progesterone induces endothelium-independent relaxation of rabbit coronary artery in vitro," Eur. J. Pharmacol. 211(1992) 163-67.
Abstract, Section CH, Week 8523, Derwent Publications Ltd., London, GB; Class B01, AN 85-139803 XP00-2055336 & SU 1 124 906 (Ivan Medicine Inst.), Nov. 23, 1984.
F.ang.hraeus, L., et al., "L-norgestrel and progesterone have different influences on plasma lipoproteins," Eur. J. Clin. Invest., vol. 13, No. 6, 1983, 447-454.
Sarrell, Philllip M., "How Progestins Compromise the Cardioprotective Effects of Estrogen," Menopause: The Journal of the North American Menopause Society, vol. 2., No. 4, 1995, pp. 187-190.
Sullivan, Jay M. et al., "Progestin Enhances Vasoconstrictor Responses in Postmenopausal Women Receiving Estrogen Replacement Therapy," Menopause: The Journal of the North American Menopause Society, vol. 2, No. 4, 1995, pp. 193-199.
Williams, J. Koudy et al., "Effects of Hormone Replacement Therapy on Reactivity of Atherosclerotic Coronary Arteries in Cynomolgus Monkeys," Journal of the American College of Cardiology, vol. 24, No. 7, Dec. 1994, pp. 1757-1761.
Belfort, Michael A. et al., "Effects of Estradiol-17.beta. and Progesterone on Isolated Human Omental Artery from Premenopausal Nonpregnant Women and from Normotensive and Preeclamptic Pregnant Women," American Journal of Obstetrics and Gynecology, vol. 174, No. 1, Part 1, Jan. 1996, pp. 246-253.
Perrot-Applanat, M. et al., "Porgesterone Receptor Expression in Human Saphenous Veins," Circulation, vol. 92, No. 10, Nov. 15, 1995, pp. 2975-2983.
Omar, Hatim. A. et al., "Properties of a Progesterone-Induced Relaxation in Human Placental Arteries and Veins," The Journal of Clinical Endocrinology and Metabolism, vol. 80, No. 2, Feb. 1995, pp. 370-373.
Stumpf, W.E., "Steroid hormones and the cardiovascular system: Direct actions of estradiol, progesterone, testosterone, gluco-and mineralcorticoids, and soltriol [vitamin D] on central nervous regulatory and peripheral tissues," Experientia, vol. 46, No. 1, Jan. 15, 1990, pp. 13-25.
Ingegno, Michael D. et al., "Progesterone Receptors in the Human Heart and Great Vessels," Laboratory Investigation, vol. 59, No. 3, Sep. 1988, pp. 353-356.
Perrot-Applanat, M. et al., "Immunocytochemical Demonstration of Estrogen and Progesterone Receptors in Muscle Cells of Uterine Arteries in Rabbits and Humans," Endocrinology, vol. 123, No. 3, Sep. 1988, pp. 1511-1519.
Bruckert, Eric et al., "Estrogens and Progestins in Postmenopausal Women: Influence on Lipid Parameters and Cardiovascular Risk," Hormone Research, vol. 43, pp. 100-103. 1995.
Sullivan, Jay M. et al., "Considerations for contraception in women with cardiovascular disorders," American Journal of Obstetrics and Gynecology, vol. 168,, No. 6, Part 2, Jun. 1993, pp. 2006-2011.
Sammour, M.B. et al., "Progesterone Therapy in Pregnancy Induced Hypertension-Therapeutic Value and Hormonal Profile," Clinical and Experimental Hypertension: Part B, Hypertension in Pregnancy, vol. B1, No. 4, 1982, pp. 455-478.
Castelo-Branco, Camil et al., "Postmenopausal Hormone Replacement Therapy with Low-Dose Medroxyprogesterone Acetate," The Journal of Reproductive Medicine, vol. 40, No. 4, Apr. 1995, pp. 305-311.
Kafonek, Stephanie D., "Postmenopausal Hormone Replacement Therapy and Cardiovascular Risk Reduction," Drugs Supplement: Treatment of Lipoprotein Disorders in Women, vol. 47, Supplement 2, 1994, pp. 16-24.
Giraud, George D. et al., "Effects of estrogen and progestin on aortic size and compliance in postmenopausal women," American Journal of Obstetrics and Gynecology, vol. 174, No. 6, Jun. 1996, pp. 1708-1718.
Barberis, Massimo C.P. et al., "Immunocytochemical Detection of Progesterone Receptors," Chest, vol. 107, No. 3, Mar. 1995, pp. 869-872.
Gaspard, U. et al., "Impact Metabolique des Oestroprogestatifs Actuels et Repercussion Cardiovascularies," Bulletin et Memoires de l'Academie royale de Medecine de Belgique, vol. 146, Nos. 8-10, 1991, pp. 334-342, at English summary on p. 341.
Horwitz, Kathryn B. et al., "Canine Vascular Tissues are Targets for Androgens, Estrogens, Progestins, and Glucocorticoids," The Journal of Clinical Investigation, vol. 69, Apr. 1982, pp. 750-758.
Gambrell, Jr., R. Don, "Use of Progestogens in Postmenopausal Women," International Journal of Fertility, vol. 34, No. 5, Sep./Oct. 1989, pp. 315-321.
Bologna William J.
Levine Howard L.
Columbia Laboratories, Inc.
Cook Rebecca
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